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研究生： Van-Hung Nguyen
Van-Hung Nguyen
論文名稱： 人體胸腰椎個體化有限元素分析於不同骨骼材料建置之生物力學研究
Biomechanical Investigation of Human Thoracolumbar Spine with Various Material Assignment Approaches Using Patient-Specific Finite Element Analysis
指導教授： 徐慶琪
Ching-Chi Hsu
口試委員: 趙振綱
Ching-Kong Chao
林鼎勝
Ting-Sheng Lin
學位類別： 碩士
Master
系所名稱： 應用科技學院 - 應用科技研究所
Graduate Institute of Applied Science and Technology
論文出版年： 2022
畢業學年度： 110
語文別： 英文
論文頁數： 111
中文關鍵詞： Thoracolumbar spine 、medical image processing 、computed tomography 、subject-specific finite element models 、material assignment approaches
外文關鍵詞： Thoracolumbar spine, medical image processing, computed tomography, subject-specific finite element models, material assignment approaches
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    • Thoracolumbar spine is the back bone of human body characterized by sophisticated material compositions with the main functions that are to support human weight as well as carry out basic human movements. Finite element analysis (FEA) with easily modified loading and boundary conditions had been widely used to develop human spine model. However, idea linear material model and short vertebral segment were considered in past studies. These assumption and simplification might affect the prediction and applicability of their numerical models. Thus, the aim of this study is to investigate human thoracolumbar spine with various material assignment approaches using patient-specific FEA.

    In this study, one subject-specific thoracolumbar spinal model with various material assignment approaches will be constructed using different computational techniques and software (Amira, Geomagic Freeform, Geomagic Wrap and ANSYS Workbench). Three thoracolumbar spinal models with different material properties will be simulated under the same loading and boundary conditions. The following biomechanical performances were analyzed and discussed including the range of motion, intersegmental rotation, intervertebral disc stress, and vertebral bone stress.
    The thoracolumbar spine models with various material assignment approaches can be successfully developed using the numerical techniques proposed by this study. The various material assignment approaches affected the intervertebral disc stress, vertebral bone stress, and intersegmental rotation of the spine models. The methodology and findings presented in this study can offer engineers as well as surgeons valuable knowledge on patient-specific thoracolumbar spine modeling and spine biomechanics.

    Thoracolumbar spine is the back bone of human body characterized by sophisticated material compositions with the main functions that are to support human weight as well as carry out basic human movements. Finite element analysis (FEA) with easily modified loading and boundary conditions had been widely used to develop human spine model. However, idea linear material model and short vertebral segment were considered in past studies. These assumption and simplification might affect the prediction and applicability of their numerical models. Thus, the aim of this study is to investigate human thoracolumbar spine with various material assignment approaches using patient-specific FEA.

    In this study, one subject-specific thoracolumbar spinal model with various material assignment approaches will be constructed using different computational techniques and software (Amira, Geomagic Freeform, Geomagic Wrap and ANSYS Workbench). Three thoracolumbar spinal models with different material properties will be simulated under the same loading and boundary conditions. The following biomechanical performances were analyzed and discussed including the range of motion, intersegmental rotation, intervertebral disc stress, and vertebral bone stress.
    The thoracolumbar spine models with various material assignment approaches can be successfully developed using the numerical techniques proposed by this study. The various material assignment approaches affected the intervertebral disc stress, vertebral bone stress, and intersegmental rotation of the spine models. The methodology and findings presented in this study can offer engineers as well as surgeons valuable knowledge on patient-specific thoracolumbar spine modeling and spine biomechanics.

    Table of Contents Acknowledgement I Abstract II Table of Contents III List of figures VI List of Tables IX Chapter 1. Introduction 1 Research background and study purpose. 1 1.1 Spine anatomy 3 1.1.1 Spinal column 3 1.1.2 Spinal curve 6 1.2 Anatomy of Vertebra 7 1.2.1 Vertebra overview 7 1.2.2 Vertebra material properties 9 1.3 Intervertebral discs 11 1.4 Spinal ligament 13 1.5 Spinal movement 14 1.6 Hounsfield scale 15 1.7 Literature review 16 Chapter 2. Material and Method 27 2.1 Visible human project 27 2.1.1 Origin, Goals, and Usage 27 2.1.2 Visible Human Male 28 2.1.3 Visible Human Female 29 2.2. Model preparation (Amira, Freeform, Geographic Wrap) 29 2.2.1 Amira (Thermo Fisher Scientific Inc, Massachusetts, U.S.) 29 2.2.2 3D Geomagic Freeform (3D Systems, Rock Hill, SC, USA) 34 2.2.3 Geometric Wrap (3D Systems, Rock Hill, SC, USA) 35 2.2.4 Ansys Workbench 2021 R1 (ANSYS, Inc., PA, USA) 36 2.3. Various material assignment approaches 41 2.3.1 Shell element model 41 2.3.2 Solid model 42 2.3.3 Material property mapping model 43 2.4 Mesh 46 2.5. Loading and boundary condition 47 2.6. Predicted results 48 Chapter 3. Result 52 3.1 Displacement distribution 52 3.2 Intervertebral discs stress 54 3.2.1 Correlation coefficient: 55 3.2.2 Extension 57 3.2.3 Lateral bending (right) 58 3.2.4 Lateral bending (left) 60 3.2.5 Axial rotation (right) 61 3.2.6 Axial rotation (left) 63 3.3 Intervertebral bone stress 65 3.3.1 Flexion 66 3.3.2 Extension 68 3.3.3 Lateral bending (right) 70 3.3.4 Lateral bending (left) 72 3.3.5 Axial rotation (right) 73 3.3.6 Axial rotation (left) 75 3.4 Range of motion and intersegmental rotation angle 77 3.4.1 Range of motion 77 3.4.2 Flexion 78 3.4.3 Extension 79 3.4.4 Lateral bending (right) 80 3.4.5 Lateral bending (left) 82 3.4.6 Axial rotation (right) 83 Chapter 4. Discussion 86 4.1 Disc stress 86 4.1.1 Flexion 86 4.1.2 Extension 87 4.1.3 Lateral bending (right) 87 4.1.4 Lateral bending (left) 87 4.1.5 Axial rotation (right) 88 4.1.6 Axial rotation (left) 88 4.2 Bone stress 88 4.2.1 Flexion 89 4.2.2 Extension 89 4.2.3 Lateral bending (right) 89 4.2.4 Lateral bending (left) 90 4.2.5 Axial rotation (right) 90 4.2.6 Axial rotation (left) 90 4.3 Intersegmental rotation angle and range of motion. 90 4.3.1 Flexion 91 4.3.2 Extension 91 4.3.3 Lateral bending (right) 92 4.3.4 Lateral bending (left) 92 4.3.5 Axial rotation (right) 92 4.3.6 Axial rotation (left) 92 4.4 Study limitations and future works. 93 Chapter 5. Conclusion 94 References 95

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