本研究旨在以矽酮高分子(Silicone)作為隱形眼鏡基材，開發具有親水性佳、抗蛋白沉積、高舒適性的多功能矽水膠隱形眼鏡，以達到長時間配戴及配戴舒適性的效果。
本研究使用聚二甲基矽氧烷(Polydimethylsiloxane, PDMS)作為基材，與異佛爾酮二異氰酸酯(Isophorone diisocyanate, IPDI)及甲基丙烯酸-2-羥基乙酯(2-hydroxy-ethyl methacrylate, HEMA) 合成矽水膠共聚物，以紫外光硬化交聯處理形成矽水膠薄膜，再進行溶劑溶脹預處理表面，以利在孔隙和表面上引入親水基團，透過過硫酸鉀(Potassium Persulfate, K2S2O8)引發形成自由基，以利聚乙烯吡咯烷酮(Polyvinyl pyrrolidone, PVP)接枝於矽水膠薄膜表面，從而改善其親水性。
由FTIR光譜觀察到在波長1650 cm-1處(醯胺末端, -C=O)有一吸收峰，顯示出PVP成功接枝於矽水膠薄膜表面。透光度在改質前後皆可達89%以上，顯示出改質並不影響其透光率。含水率及透氧率經改質後有些微的提升，但抗拉強度及延伸性都變差。而親水性方面，改質前與改質後表面接觸角降低約45°，表面親水性有明顯提升。經原子力顯微鏡量測，表面粗糙度隨改質時間延長而提升。利用BCA蛋白質測定可得知，改質後矽水膠能有效降低表面蛋白質吸附。細胞毒性經ISO-10993-5判斷為無毒性。
綜合以上結果，PDMS-PU-HEMA經由表面接枝PVP的方式改質，改質後的矽水膠，具有適當的透光性、透氧性、親水性及抗蛋白沉積，且無細胞毒性。儘管其抗拉強度及延伸性較差，但此矽水膠改質的新方法，對於做為眼科鏡片材料的應用具有良好的潛力。

This study is aiming to modify the surface of silicone hydrogel contact lenses with poly(vinyl pyrrolidone) (PVP). The resultant contact lenses exhibited high wettability, anti-adhesion of proteins and high hydrophilicity. Our goal is to create more comfortable and longer-term contact lenses.
To meet our goal, PVP is grafted to the surface of the contact lenses (PDMS-PU-PVP). A solvent swelling pre-treatment is carried out to introduce hydrophilic groups in the pores and on the surface. The modification is performed through chemical cross-linking and grafting of PVP by using potassium persulfate (K2S2O8) as a radical initiator. The resultant contact lenses exhibited reduced protein deposition and lower water contact angle. On the other hand, the optical transparency and water content showed no significantly change. In addition, the oxygen permeability (Dk) would remain up to 76 barrer which is the Dk of the PDMS-PU-HEMA control group. Furthermore, in vitro L929 fibroblasts assay showed that these hydrogels were non-cytotoxic. However, the mechanical properties of the contact lenses decreased with increasing modification time.
Overall results demonstrated that the PDMS-PU-PVP hydrogels exhibited not only high oxygen permeability and optical transparency, but also hydrophilicity and anti-protein adsorption. Therefore, in spite of the lower mechanical properties, this new modification method exhibited a good potential in the application of ophthalmic lenses.

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