本研究旨在以 DLP 3D 列印法開發可生物降解的神經導管。為了實現這一目標，本研究以甲基丙烯酸酐（MAAH）將聚乳酸（PLA）和己二酸共對苯二甲酸二乙二醇酯（PATDEG）進行末端封端，製備了 UV 可固化樹脂。首先，將 PLA 和PATDEG 以乙二醇解聚合，產生寡聚體，然後再與 MAAH 反應，使得 PLA 和PATDEG 的 鏈 末 端 帶 有 甲 基 丙 烯 酸 酯 官 能 團 。 然 後 將 PLA-DIMA 和PATDEG-DIMA 以不同比例混合，並使用 DPPH 作為自由基清除劑，通過 DLP 3D列印進行 UV 固化，製備出微凹槽神經導管。製備得到的神經導管經過力學測試和生物相容性測試。在 3D 可列印性方面，添加了 0.0375%和 0.05%的 DPPH，所得之神經導管，其尺寸和形狀與預期設計非常接近。此外，較高的 PATDEG含量提高了導管的柔軟性。所有的 PLA/PATDEG 組合對相對細胞生長性都沒有顯著影響。因此顯示 PLA/PATDEG 具有生物相容性，適於生物醫學之應用。

This research aims to develop a biodegradable nerve conduit through DLP 3D
printing process. In order to achieve this goal, UV-curable resins were prepared by
end-capping poly(lactic acid) (PLA) and poly(adipate co-terephthalate diethylene
glycol) (PATDEG) with methacrylic anhydride (MAAH). Firstly, PLA and PATDEG
were glycolyzed to produce oligomers before reacting with MAAH to create PLA and
PATDEG with methacrylate functional groups at both the ends of the chain. The
PLA-DIMA and PATDEG-DIMA were mixed in various proportions and UV-cured
using DLP 3D printing into microgrooved nerve conduits with DPPH as the free
radical scavenger. The printability results show that the nerve conduits prepared with
0.0375% and 0.05% DPPH exhibited a dimension and shape that closely resembled
the intended design. Furthermore, higher PATDEG content more flexible conduits. In
addition, all the PLA/PATDEG compositions exhibited no significant effect on
relative cell growth. Thus PLA/PATDEG is biocompatible and safe for use in
biomedical applications

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