碳納米角是碳同素異形體之一，呈約100 nm大小的球形結構。它的石墨成分使其對不同類型的芳香族系列藥物分子具有很高的吸附能力，可用於抗癌化學療法。特別是，對碳納米角進行酸處理時，會有羥基,羧酸和醚等官能化。此外，由於已確認它們對人體無毒，因此它們是優選的候選藥物遞送載體之一。因此，在這項工作中，我們專注於使用碳納米角作為化學療法，熱療和光動力療法（PDT）等組合療法的遞送系統。表現出良好的磁響應的氧化鐵納米粒子能夠進行高溫治療。同時，碳點由於其產生單一態氧的特性而具有光動力學療法（PDT）。
對於共同裝載的藥物實驗，喜樹鹼和吉西他濱連續地被裝載在碳納米角上。測量了吉西他濱釋放的溫度依賴性，在較高溫度下提高藥物釋放，但喜樹鹼未釋放。對於PDT研究，測量了CNHacid/Fe3O4 @ Cdots產生的單一態氧。此外，已經進行了藥物釋放和光照射的組合，並顯示出良好的藥物釋放結果。

Carbon nanohorns are one of carbon allotropies and take a spherical structure of about 100 nm size. Its graphitic component makes them to have high adsorption capacity of different types of aromatic series drug molecules for anti-cancer chemotherapy. Especially, when Carbon nanohorns were acid-treated, it was functionalized by hydroxyl, carboxyl acid, ether and so on. Moreover, since they are confirmed to be nontoxic on human bodies, they are one of preferable candidates as drug delivery carrier. Thus, in this work, we focus on the use of carbon nanohorns as a delivery system for combination therapy like chemotherapy, hyperthermia and photodynamic therapy (PDT). Iron oxide nanoparticles that displayed a good magnet response were capable of hyperthermia. Meanwhile, the carbon dots due to its property to generate singlet oxygen were capable of photodynamic therapy (PDT).
For co-loading drug experiment, camptothecin and gemcitabine were loaded sequentially on carbon nanohorns. The temperature dependency of gemcitabine release was measured and resulted higher drug release in higher temperature, although camptothecin didn’t release.
For the PDT study, the singlet oxygen generated by carbon nanohron/Fe3O4@carbon dots was measured. Furthermore, the combination of drug release and light irradiation has been performed and showed a good result in drug release.

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