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研究生: 廖誼憲
Yi-Hsien Liao
論文名稱: 聚酯基底之栗殼纖維複合材其性質與生物相容性之研究
Characterization and Biocompatibility of Chestnut Shell Fiber–Based Composites with Polyester
指導教授: 蘇舜恭
Shuenn-kung Su
口試委員: 邱智瑋
Chih-Wei Chiu
吳進三
Chin-San Wu
林麗惠
none
學位類別: 碩士
Master
系所名稱: 工程學院 - 材料科學與工程系
Department of Materials Science and Engineering
論文出版年: 2015
畢業學年度: 103
語文別: 中文
論文頁數: 68
中文關鍵詞: 共混生物降解性生物相容性纖維聚酯
外文關鍵詞: blend, degradability, biocompatibility, fiber, polyester
相關次數: 點閱:331下載:2
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本研究為評估栗殼纖維(CSF)與聚丁二酸丁二醇酯(PBS)之複合材(PBS/CSF),及經交聯反應之栗殼纖維(TCSF)與PBS接枝順丁烯二酸酐(PBS-g-MA)之複合材(PBS-g-MA/TCSF)之結構、機械性質、生物相容性與生物降解性。
研究發現PBS-g-GMA/TCSF相較於單純之PBS與PBS/CSF複合材,有較好的機械性質,可歸因於PBS-g-MA與TCSF之間擁有較佳之兼容性。將常人之包皮纖維細胞(FBs)接種於這兩種複合材上以測試生物相容性;結果顯示出,附著於PBS/CSF複合材上之FBs,其細胞增生率、膠原蛋白增生與細胞毒性測定,皆優於PBS-g-MA/TCSF複合材;而PBS-g-MA/TCSF複合材較PBS/CSF有較好的抗水性。另將兩種系列之複合材埋入土壤堆肥中測試後,皆有重量的損失,指出兩種複合材皆有生物降解性,且生物降解性會隨CSF濃度上升而升高。


The structural, mechanical, biocompatibility, and bio- degradability properties of composite materials formed of poly(butylenes succinate; PBS) and natural fiber (chestnut shell fiber; CSF) were evaluated. Maleic anhydride-grafted PBS (PBS-g-MA) and treated (crosslinked) CSF (TCSF) were used to improve the mechanical properties of PBS/CSF composites. The results show that PBS-g-MA/TCSF composites have superior mechanical properties compared with both pure PBS and PBS/CSF composites, which is attributed to better compatibility between the polymer and TCSF. Normal human foreskin fibroblasts (FBs) were seeded onto these two series of composites to characterize the biocompatibility. FB proliferation, collagen production, and cytotoxicity assays on the PBS/CSF series of composites exhibited superior results compared with those on the PBS-g-MA/TCSF composites. PBS-g-MA/TCSF was found to be more water resistant than PBS/CSF, and the weight loss of both the composites buried in soil compost indicated that both were biodegradable, especially at high levels of CSF substitution.

摘要---------------------------------------------------------I Abstract----------------------------------------------------II 總目錄-----------------------------------------------------III 圖表索引----------------------------------------------------VI 第一章 緒論--------------------------------------------------1 1.1 前言--------------------------------------------------1 1.2 目的--------------------------------------------------3 第二章 文獻回顧----------------------------------------------4 2.1 可生物降解聚合物簡介-----------------------------------4 2.1.1 可降解聚合物起源與發展-----------------------------4 2.1.2 可生物降解聚合物種類-------------------------------6 2.1.3 可生物降解聚合物之應用-----------------------------8 2.2 PBS簡介------------------------------------------------9 2.2.1 PBS緣起--------------------------------------------9 2.2.2 PBS合成方式---------------------------------------11 2.2.3 PBS之生物降解原理---------------------------------12 2.2.4 PBS之應用-----------------------------------------12 2.3 順丁烯二酸酐簡介--------------------------------------14 第三章 實驗方法與原理---------------------------------------15 3.1 實驗方法----------------------------------------------15 3.1.1 實驗藥品------------------------------------------15 3.1.2 實驗儀器------------------------------------------17 3.1.3 PBS-g-MA共聚物之配製------------------------------18 3.1.4 CSF與TCSF之配製-----------------------------------20 3.1.5 PBS複合材配置-------------------------------------21 3.2 性質測定----------------------------------------------23 3.2.1 NMR、FTIR分析-------------------------------------23 3.2.2 機械性質測試--------------------------------------25 3.2.3 複合材之表面型態觀察------------------------------25 3.3 人體包皮纖維芽細胞對於PBS系列複合材之生物機能測定-----27 3.3.1 細胞與培養基--------------------------------------27 3.3.2 細胞增殖測定--------------------------------------27 3.3.3 膠原蛋白定量--------------------------------------28 3.3.4 細胞毒性評估--------------------------------------29 3.3.5 吸水率--------------------------------------------29 3.3.6 生物降解研究--------------------------------------30 第四章 結果與討論-------------------------------------------31 4.1 PBS與其複合材料之材料性質-----------------------------31 4.1.1 FTIR----------------------------------------------31 4.1.2 NMR-----------------------------------------------34 4.2 表面形態及機械性能------------------------------------37 4.2.1 SEM-----------------------------------------------37 4.2.2 萬能材料試驗機試驗--------------------------------39 4.3 PBS與其複合材料之生物相容性---------------------------41 4.3.1 細胞增殖率----------------------------------------41 4.3.2 膠原蛋白定量--------------------------------------43 4.3.3 細胞毒性檢測--------------------------------------47 4.3.4 吸水性測試----------------------------------------49 4.3.5 生物降解性----------------------------------------50 第五章 結論-------------------------------------------------54 參考文獻----------------------------------------------------55

[1] Azadeh, S.; Murugan R.; Imen, E. H.; Serge, O.; K. Ali. Acta Biomater. 2011, 7, 1441.
[2] Holzapfel, B. M.; Reichert, J. C.; Schantz, J. T.; Gbureck, U.; Rackwitz, L.; N th, U.; Jakob, F.; Rudert, M.; Groll, J.; Hutmacher, D. W. Adv. Drug. Deliv. Rev. 2013, 65, 581.
[3] Burnouf, T.; Goubran, H. A.; Chen, T. O.; Ou, K. L.; Magdy, E.; Radosevic, M. Blood Rev. 2013, 27, 77.
[4] Xiang, Y.; Wang, Y.; Luo, Y.; Zhang, B.; Xin, J.; Zheng, D. Colloids Surf. B 2011, 85, 248.
[5] Kundu, B.; Rajkhowa, R.; Kundu, S. C.; Wang, X. Adv. Drug. Deliv. Rev. 2013, 65, 457.
[6] Kim, G.; Rho, Y.; Park, S.; Kim, H.; Son, S.; Kim, H.; Kim, I. J.; Kim, J. R.; Kim, W. J.; Ree, M. Biomaterials 2010, 31, 3816.
[7] Peter, M.; Binulal, N. S.; Soumya, S.; Nair, S. V.; Furuike, T.; Tamura, H.; Jayakumar, R. Carbohydr. Polym. 2010, 79, 284.
[8] You, Z.; Cao, H.; Gao, J.; Shin, P. H.; Day, B. W.; Wang, Y. Biomaterials 2010, 31, 3129.
[9] Nair, L. S.; Laurencin, C. T. Prog. Polym. Sci. 2007, 32, 762. 56
[10] Ko, Y. G.; Ma, P. X. J. Colloid Interface Sci. 2009, 330, 77.
[11] Lovell, C. S.; de Oca, H. M.; Farrar, D.; Ries, M. E.; Ward, I. M. Polymer 2010, 51, 2013.
[12] Pan, P.; Inoue, Y. Prog. Polym. Sci. 2009, 34, 605.
[13] Liang, J.; Zhou, L.; Tang, C. Y.; Tsui, C. P.; Li, F. J. Polym. Test 2012, 31, 149.
[14] Weng, Y. X.; Jin, Y. J.; Meng, Q. Y.; Wang, L.; Zhang, M.; Wang, Y. Z. Polym. Test 2013, 32, 918.
[15] Liu, L.; Yu, J.; Cheng, L.; Yang, X. Polym. Degrad. Stab. 2009, 94, 90.
[16] Kim, H. S.; Kim, H. J.; Lee, J. W.; Choi, I. G. Polym. Degrad. Stab. 2006, 91, 1117.
[17] Phua, Y. J.; Lau, N. S.; Sudesh, K.; Chowa, W. S.; Mohd Ishak, Z. A. Polym. Degrad. Stab. 2012, 97, 1345.
[18] Zhao, Q.; Tao, J.; Yam, R. C. M.; Mok, A. C. K.; Li, R. K. Y.; Song, C. Polym. Degrad. Stab. 2008, 93, 1571.
[19] Wong, K. J.; Zahi, S.; Low, K. O.; Lim, C. C. Mater. Des. 2010, 31, 4147.
[20] Prasad, A. V.; Rao, K. M. Mater. Des. 2011, 32, 4658.57
[21] De Vasconcelos, M. C. B. M.; Bennett, R. N.; Rosa, A. S. E.; Ferreira-Cardoso, J. V. J. Sci. Food Agric. 2010, 90, 1578.
[22] 蘇明德‘能自動分解的塑膠-可降解塑膠’科學發展 2010, 446, 64-67
[23] 黃賜源 ‘生分解材料分解發展現況’
[24] 化學工業日報 2001 02 19
[25] 李成濤,張敏,歐陽亮,劉俊玲,蘇康宇,邱建輝 ‘聚丁二酸丁二醇酯(PBS)生物降解過程對植物生長的影響評價’ 生態環境學報 2011, 20(1): 181-185
[26] Hwang, S. W.; Lee, S. B.; Lee, C. K.; Lee, J. Y.; Shim, J. K.; Selke, S. E. M.; Soto-Valdez, H.; Matuana, L.; Rubino, M.; Auras, R. Polym. Test 2012, 31, 333
[27] Umare, S. S.; Chandure, A. S.; Pandey, R. A. Polym. Degrad. Stab. 2007, 92, 464.
[28] Xiong, Z.; Li, C.; Ma, S.; Feng, J.; Yang, Y.; Zhang, R.; Zhu, J. Carbohydr Polym 2013, 95, 77.
[29] Yao, Z.; Qi, J.; Wang, L. J Food Sci 2012, 77, C671.
[30] Kim, H. S.; Lee, B. H.; Choi, S. W.; Kim, S.; Kim, H. J. Compos Part A 2007, 38, 1473.
[31] Pothan, L. A.; Thomas, S.; Groeninckx, G. Compos Part A 2006, 5837, 1260.
[32] Kuwabara, K.; Gan, Z.; Nakamura, T.; Abe, H.; Doi, Y. Biomacromolecules 2002, 3, 1095.
[33] Ranganathan, S.; Baker, W. E.; Russell, K. E.; Whitney, R. A. J. Polym. Sci. Part A: Polym. Chem. 1999, 37, 3817.
[34] Wu, C. S.; Liao, H. T. Des. Monomers Polym. 2003, 6, 1.
[35] Trana, L. Q. N.; Fuentesa, C. A.; Dupont-Gillain, C.; Van Vuure, A. W.; Verpoest, I. Colloids Surf. A 2011, 377, 251.
[36] Nam, K.; Kimura, T.; Funamoto, S.;Kishida, A. Acta Biomater. 2010, 6, 409.
[37] Sivakumar, L.; Agarwal, G. Biomaterials 2010, 3, 4802.
[38] Grover, C. N.; Cameron, R. E.; Best, S. M. J. Mech. Behav. Biomed. Mater. 2012, 10, 62.
[39] Veleirinho, B.; Coelho, D. S.; Dias, P. F.; Maraschin, M.; Ribeiro-do-Valle, R. M.; Lopes-da-Silva, J. A. Int. J. Biol. Macromol. 2012, 51, 343.
[40] Bhattacharyya, S. S.; Paul, S.; De, A.; Das, D.; Samadder, A.; Boujedaini, N.; Khuda-Bukhsh, A. R. Toxicol. Appl. Pharmacol. 2011, 253, 270.

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