本論文之目標為合成含磺基甜菜鹼 (sulfobetaine methacrylate, SBMA) 兩性離子的高分子、以及甲基丙烯酸聚乙二醇酯(poly(ethylene glycol methacrylate), PEGMA)高分子，進行材料表面處理，並藉由血小板及纖維蛋白原吸附、及血漿凝固時間測試，評估材料表面血液相容性。在合成SBMA及丙烯酸 (acrylic acid, AA)單體之共聚合物poly(SBMA-co-AA)方面，改變共聚合物中SBMA之比例，以及共聚合物吸附時的環境pH值，利用多層膜堆疊技術，進行血液相容性測試。結果顯示由poly(SBMA56-co-AA44)於pH 3.0條件下所製備的表面，最能有效抑制血小板及纖維蛋白原之吸附。同時，多層膜堆疊技術可應用於不同基材表面，且此改質方式於酸性、鹼性環境中，皆具有良好之穩定性，可維持其抑制血小板吸附之特性。
在合成poly(PEGMA-co-AA)共聚合物的研究方面，探討接枝具有光敏感性疊氮苯胺 (azidoaniline, Az)之效應，合成poly(PEGMA-co-AA-g-Az)。實驗結果顯示poly(PEGMA-co-AA-g-Az)所修飾之表面可大幅降低血小板及纖維蛋白原吸附，同時血小板吸附量亦隨共聚合物塗佈量之增加而減少。另外，具有較高的PEGMA含量所修飾之表面，具有較佳的血液相容性。含疊氮苯胺之共聚高分子可經交聯修飾表面，在酸性以及鹼性環境中皆具有良好之穩定性，可有效抑制血小板吸附。在應用方面，利用所合成之共聚合高分子修飾於微流道，並進行流動狀態下之血小板吸附測試，結果顯示在不同的剪切速率環境下，兩種高分子所修飾之表面皆能有效降低血小板吸附，顯示此兩種共聚合物可廣泛應用於修飾不同材料之表面，於靜態以及動態情形下皆能抑制血小板貼附，提供材料優異之血液相容性。

In this thesis, the copolymers containing sulfobetaine methacrylate (SBMA) and poly(ethylene glycol) methacrylate (PEGMA) moieties were synthesized and employed for surface modifications. The hemocompatibility of the modified surfaces was evaluated by platelet adhesion, fibrinogen adsorption, and plasma clotting time tests. The poly(SBMAx-AAy) copolymers were immobilized onto polymeric substrates by layer-by-layer polyelectrolyte deposition and the coating demonstrated excellent resistance to platelets and fibrinogen adsorption. Moreover, this technique is applicable for various substrates and possesses great durability under acid and basic conditions. On the other hand, the surface modified with photosensitive azidoaniline (Az) grafted poly(PEGMA-co-AA-g-Az) revealed excellent blood compatibility that significantly inhibited platelet adhesion and fibrinogen adsorption. Moreover, the effect was promoted by the increased casting volume and with higher PEGMA ratio in copolymers. Az group assisted the crosslinking of poly(PEGMA-co-AA) onto substrate which supported the stability of the coating of copolymers under rigorous conditions. Finally, we demonstrated that the coatings of both poly(SBMA-co-AA) and poly(PEGMA-co-AA-g-Az) onto PDMS micro-fluidic channels which mimics the blood flow system maintained excellent platelets resistance. The overall results indicated the synthesized copolymers are applicable on a wide range of substrates with superior hemocompatibility and stability under both static and dynamic which can be further applied in biomedical applications.

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