本研究主要目的為探討生物可相容緩衝劑（HEPES-Na）或新型離子液體（[TMA][EPPS]）添加於有機水溶液中的液液平衡行為研究，在298.2 K常壓下。本實驗系統中所研究的有機溶劑分別為1,3-二氧五環、1,4-二氧陸圜、乙腈及叔丁醇。因添加第三成分緩衝劑（HEPES-Na）或離子液體（[TMA][EPPS]）於有機水溶液中時，其離子易與水產生水合作用，使溶液分離成兩液相，其分別為有機相及水相。實驗利用雲點法量測相邊界組成及分析法量測液液兩相區內的縛線組成。以Othmer-Tobias關聯式檢驗LLE數據具有良好的一致性，並以熱力學模式NRTL關聯LLE數據，獲取交互作用參數的最適值。

The main objective of this study is to investigate liquid-liquid equilibrium (LLE) behavior of azeotropic organic aqueous solutions in the present of biological compatible buffer (HEPES-Na) or new ionic liquid ([TMA][EPPS]) at 298.2 K and atmospheric pressure. The organic solvents of 1,3-dioxolane, 1,4-dioxane, acetonitrile and tert-butanol were studied in this work. As the third component, buffer or ionic liquid, was added, the ions of buffer or ionic liquid would form strong interactions with water; therefore, the mixtures would be divided into two-liquid phases, aqueous phase and organic phase. The phase boundary data were measured by cloud point and the LLE data by analytical method. The consistency of the tie-line data was confirmed by the Othmer-Tobias correlation. The LLE data were correlated with the NRTL model and the optimal interaction parameters were obtained by the data reduction.

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