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研究生: 周文揚
Wen-yang Chou
論文名稱: 整合式電子化心電與心音訊號監測裝置之研製
Implementation of integrated electronic electrocardiogram and stethoscope device for heart sound signals monitoring.
指導教授: 蔡明忠
Ming-jong Tsai
口試委員: 趙福杉
Fu-shan Jaw
沈永康
Yung-kang Shen
邱綺文
Che-wun Chiou
阮張榮
Chang-jung-Juan
鄭逸琳
Yih-lin Cheng
學位類別: 博士
Doctor
系所名稱: 工程學院 - 自動化及控制研究所
Graduate Institute of Automation and Control
論文出版年: 2012
畢業學年度: 100
語文別: 英文
論文頁數: 110
中文關鍵詞: 心音心電圖聽診器電子聽診器藍芽無線Butterworth 濾波器
外文關鍵詞: Stethoscope, Butterworth filter
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聽診器和心電圖至今仍是心臟科醫師對於心臟診斷的主要工具。但聽診器的結構具有一些缺點。例如,聲音在Y型管內傳導時被衰減,沒有儲存裝置,容易受周圍雜音干擾以及受限於Y型管的長度,使得操作範圍被限制。心電圖的缺點是體積大,價格昂貴,以及操作不便。本文基於心電與心音訊號之監測,完成整合式電子化心音及心電訊號監測裝置的研究與製作。比照聽診器的特性,以電容式麥克風為感測器,經過適當的寬頻Butterworth帶通濾波器的濾波與放大器放大,以及錄放音單元電路,設計出電子式聽診器。以具有高輸入阻抗、高共模拒斥比以及低雜訊的儀表放大器設計為心電圖電路的第一級放大,適當的放大倍數以及濾波頻寬,結合藍芽無線模組,完成單導程心電圖監視器電路設計。完成的電子聽診器,將濾波後的心音放大10倍,共8軌且每軌7.5秒的錄放音功能。以ISM頻段的無線模組取代Y型管,增加聽診使用距離。完成的單導程藍芽無線心電監視器具有600倍的放大率,頻率響應為0.5Hz~40Hz。心電監視器組裝於軟性電路板,可以配合人體表面的形狀而彎曲,並慎選微小型電子零組件,達到微小化目的,同時通過電磁相容規範的測試。將心音和心電二者的電路整合在一起,形成双通道擷取電路。處理後的心音和心電信號便可經由電腦音效卡傳送到電腦做進一步的處理。心音和心電信號擷取電路已完成設計與製作。本著以上技術,只要適當調整放大倍率和濾波頻寬,很快便可以應用於其他生理信號的擷取與監測,縮短設計時間,同時對於病歷電子化也有相當幫助。


Cardiologists still rely on acoustic auscultation for diagnosing heart diseases by using acoustic stethoscopes and electrocardiograms (ECG). However, the acoustic stethoscope has some shortcomings such as sound intensity loss in the tubing, no storage capacity, short range of operation and ambient noise interference. High cost, difficulty of operation and large volume are disadvantages of an ECG. This dissertation proposes an integrated electronic ECG and stethoscope device for heart signals monitoring. Heart sound is picked up by an electret condenser microphone. It is then filtered by a Butterworth bandpass filter and amplified. Later, a recording circuit is designed for the electronic stethoscope. A first stage amplifier of ECG is a high input impedance, high common-mode rejection ratio and low noise of instrumentation amplifier. A single lead ECG monitor circuit is implemented with appropriate amplification, filtration and a Bluetooth wireless module. The implemented electronic stethoscope has 10 times amplification after filtration of heart sound, and the recorder function has a total of 8 tracks, with 7.5 seconds in each track. A wireless module with ISM band replaces Y-shape tubing to increase operation distance. The single lead wireless ECG monitor has 600 times amplification and 0.5Hz~40Hz frequency response across its operation range. The ECG monitor is built on a flexible printed circuit board to fit human body shape, in which all unit components were carefully selected to minimize unit size. The measurement result of electromagnetic compatibility (EMC) is also passed. An integrated heart sound and ECG acquisition unit has been implemented to synchronously pick up heart sounds and ECG signals for computerized recording and further analysis of heart sounds, which can be extended quickly to acquire related signals.

中文摘要 I Abstract II 誌謝 III Contents IV List of Symbols VII List of Figures IX List of Tables XIV Chapter 1 Introduction 1 1-1 Background 1 1-2 Motivation and objectives 7 1-3 Literature Review 8 1-4 Organization of this dissertation and study map 11 Chapter 2 Design of an electronic stethoscope circuit 14 2-1 Pick-up Head 14 2-2 Pre-Amplifier 15 2-3 Band Pass Filter of Mode 16 2-4 Micro-controller 22 2-5 Recorder unit 23 2-6 Power Sources 24 2-7 Electronic switch 25 2-8 Power amplifier 26 2-9 Speaker 26 Chapter 3 Design of an electrocardiogram circuit 27 3-1 Electrode 28 3-2 ECG amplifier circuit 29 3-2-1 First stage amplifier 29 3-2-2 High pass filter 31 3-2-3 Low pass filter 32 3-2-4 Driver right leg circuit 33 3-3 Micro-controller unit 34 3-4 Wireless module 35 3-5 Notch filter 35 3-5-1 Twin-T notch filter 37 3-5-2 Notch filter with Universal Active Filter 38 Chapter 4 Implementation and results 40 4-1 Implementation of electronic stethoscope 40 4-2 Results of the electronic stethoscope 46 4-3 Implementation of a novel split-type wireless electronic stethoscope 47 4-4 The results of a NSWES 52 4-5 Implementation of a flexible wireless ECG monitor 55 4-6 Results of a flexible wireless ECG monitor 58 4-7 Implementation of an integrated heart sound and ECG unit 64 4-8 Result of an integrated heart sound and ECG unit 67 Chapter 5 Discussion 70 5-1 Discussion of the electronic stethoscope implementation 70 5-2 Discussion of the NSWES implementation 71 5-3 Discussion of the flexible wireless ECG monitor implementation 73 5-4 Discussion of an integrated heart sound and ECG unit implementation 78 Chapter 6 Conclusions and future work 80 6-1 Conclusions 80 6-2 Future work 82 Reference 83 作者簡介 96

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