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研究生: 楊和興
HO-HSING YANG
論文名稱: 深入探討三酸甘油脂T2校正中的非指數衰減
More Detailed Investigation of Non-exponential T2 decay of Triglyceride
指導教授: 林益如
Yi-Ru Lin
口試委員: 黃騰毅
蔡尚岳
學位類別: 碩士
Master
系所名稱: 電資學院 - 電子工程系
Department of Electronic and Computer Engineering
論文出版年: 2019
畢業學年度: 107
語文別: 英文
論文頁數: 44
中文關鍵詞: 三酸甘油脂T2校正磁共振頻譜
外文關鍵詞: Triglyceride, T2 correction, Magnetic Resonance Spectroscopy
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磁共振頻譜(MRS)是一種非侵入性技術,能夠用於測量不同化學成
分的濃度,現在許多研究採用磁共振頻譜作為研究腦中代謝物、肌肉、
腫瘤和肝臟脂肪代謝物的主要工具。這個技術比以往需要採集組織分
析的診斷方法更能讓大眾接受。由於磁共振頻譜安全且非侵入式的特
性,該技術在臨床上的應用也逐年增加。在之前的研究中,Gavin
Hamilton 提出使用不同的單體素磁共振頻譜序列定量出的三酸甘油
脂濃度有所不同,他並提出研究結果顯示STEAM 序列結合短TE 的使
用可以穩定且正確地定量出三酸甘油脂的飽和比例。在本研究中,我
們希望可以確認STEAM 序列量測三酸甘油脂的正確性,我們使用多個
TE 參數對兩種油品進行多次的量測,發現即使使用STEAM 序列,各
尖峰的T2 衰減趨勢並非單一指數衰減,並且在不同油品及不同次的
量測中均有相同的衰減趨勢,根據測量結果所計算出的飽和比例,會
有誤差。


Magnetic Resonance Spectroscopy (MRS) is a noninvasive technique that can be used to measure the concentrations of different chemical components. Many studies adopt MRS as a useful tool to investigate the metabolite of brain, muscle, tumor and hepatic fat. Comparing to the tissue biopsy, MRS provides safe and noninvasive diagnosis. Thus, this technique is increasingly applied on the clinical field. In this study, we used MRS technique to elevate triglyceride. In previously research, Gavin Hamiltom et al. figured out that different sequences provide different fat fraction and T2 values by single-voxel spectroscopy (SVS). Therefore, we first tested the parameters of the oil and cross-validation using the chart proposed by Gavin Hamiltom et al. Then measure the triglyceride in the T2 decay signal to estimate the original signal, which is different from the theoretical value. We used two different oils to compare the T2 decay curve of different oils. And trying to find a set of TE sequences in pure oil can bring the measured values closer to the theoretical value. According to the previous information on oil-water mixing, a method for making oil-water phantom is provided. The TE sequence found by pure oil is applied to the above.

Abstract ................................................................................................................ 1 摘要 ..................................................................................................................... 2 誌謝 ..................................................................................................................... 3 List of Contents ..................................................................................................... 4 List of Figures ...................................................................................................... 5 List of Tables ......................................................................................................... 6 Chapter 1. Introduction ......................................................................................... 7 1.1 Triglyceride .............................................................................................. 7 1.2 1H-MRS .................................................................................................... 8 1.3 Phantom ................................................................................................. 10 1.4 Single voxel spectroscopy (SVS) ............................................................... 10 1.4.1 Stimulated Echo Acquisition Mode (STEAM) ......................................... 11 1.5 Motivation .............................................................................................. 12 Chapter 2. Material and Method .......................................................................... 13 2.1 Calculate parameter ................................................................................ 13 2.2 Phantom manufacture ............................................................................ 13 2.3 Experiments and Data Processing ............................................................ 14 2.4 Quantification ......................................................................................... 15 2.5 T1&T2 correction .................................................................................... 16 2.6 Select best TE .......................................................................................... 17 Chapter 3. Results ................................................................................................ 19 3.1 Calculate Parameter ................................................................................ 19 3.2 Gaussian fitting ....................................................................................... 21 3.3 T1&T2 correction .................................................................................... 25 3.4 T2 decay trend ........................................................................................ 28 3.5 Select TE Protocol ................................................................................... 32 Chapter 4. Discussion ........................................................................................... 35 4.1 Quantification ......................................................................................... 35 4.2 Selected TE Protocol ............................................................................... 36 4.3 Phantom manufacture ............................................................................ 39 Chapter 5. Reference ............................................................................................ 40

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