生物膜主要是由微生物所分泌的胞外高分子物質包覆微生物所構成，在醫療、工業、海洋船隻、運輸管線與食品加工等皆會造成嚴重問題，當微生物一旦在物體表面形成生物膜後不易被消除，因此事先防止生物膜的形成會比事後去除來的有效。本論文依據Aizenberg所提之光滑注液多孔表面(SLIPS)理論，利用微孔高分子薄膜上製備出SLIPS，並應用於抗生物膜之研究。
首先利用多巴胺可在各種材料表面形成聚多巴胺的特性，將微孔PE薄膜表面以聚多巴胺改質，再利用含硫醇之氟系分子使表面氟化，接著將氟系潤滑油K103浸潤於薄膜之微孔結構中，發現聚多巴胺塗層後並氟化並無法增加K103浸潤之含量及其穩定性，而直接將PE膜以K103浸潤(PEK)即可獲得穩定性良好的K103塗層，並可降低94 %的蛋白質吸附量及79 %的生物膜形成量。
礦物油、蔬菜油與K103皆可直接浸潤於PE膜中，以蔬菜油浸潤之PEV無法抗生物膜形成，而以礦物油浸潤之PEM可降低51 %生物膜形成量，以K103浸潤之PEK可降低71 %生物膜形成量，而PEK穩定性又較PEM來得好。
以K103浸潤不同孔徑大小之PTFE、PP、ZIP與PE膜，發現薄膜孔徑越大，其經SDS清洗之K103損失量越多，而抗蛋白質吸附之效果依序為PEK(70 %) > PPK(60 %) > PTFEK(33 %)，抗生物膜形成之效果依序為PTFEK(76 %) > PEK(67 %)≧PPK(64 %)，但從生物膜形成量來看PEK與PTFEK的結果最相近。

Bacteria once attach onto surfaces move and secrete extracellular polymeric substance to form biofilm. The bacterial communities have inherent resistance to antimicrobial agents and mechanical stress that leads to serious problems in the medical, industrial, marine vessels, transport pipelines and food processing. Therefore, prevention biofilm formation beforehand will be more effective than remove it afterword. Recently, Slippery Liquid-Infused Porous Surfaces (SLIPS) have been reported to have very effective anti-biofilm property. In this work, liquid-infused microporous film was studied for it anti-biofilm capability. The results show that protein adsorption can be reduced 94%. S.aureus biofilm formation over a 7-d period can also be reduced 79% when SLIPS surface were employed. Both microporous polyethylene and polypropylene surfaces resulted in biofilm formation within 8 hours. However, K103-infused PE shows approximately 2 fold reduction of protein adsorption and nearly low extent of S.aureus biofilm formation in comparison of K103-infused PTFE. We also found that fluorinated oil can directly infuse into the micropore of films without fluorinating the microporous film. The porous film with average pore size of 50nm and 6 % porosity enable K103 oil directly infuse the film and remained stable under SDS and sonication wash.

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