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研究生: 莊承憲
Cheng-Hsien Chuang
論文名稱: 喉內視鏡客觀量化量測模組之3D列印設計及應用於阻塞型睡眠呼吸中止症之實際臨床診斷與驗證
3D printing design of objective quantitative measurement module of laryngeal endoscope and its application in actual clinical diagnosis and verification of obstructive sleep apnea
指導教授: 郭中豐
Chung-Feng Jeffrey Kuo
黃昌群
Chang-Chiun Huang
口試委員: 劉紹正
Shao-Cheng Liu
邱錦勲
Chin-Hsun Chiu
學位類別: 碩士
Master
系所名稱: 工程學院 - 材料科學與工程系
Department of Materials Science and Engineering
論文出版年: 2020
畢業學年度: 108
語文別: 中文
論文頁數: 93
中文關鍵詞: 口咽內視鏡影像雷射投影模組相關性分析ROC曲線睡眠呼吸中止症喉內深度量測口咽部截面積
外文關鍵詞: laryngoscopy, laser projection module, correlation analysis, ROC curve, sleep apnea, laryngeal depth measurement, oropharyngeal cross-sectional area
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  • 摘要 I Abstract III 致謝 V 目錄 VI 圖目錄 IX 表目錄 XI 第 1 章 緒論 1 1.1 研究動機 1 1.2 文獻回顧 3 1.2.1 喉內視鏡雷射投影 3 1.2.2 檢測方法之回顧 6 1.2.3 鏡頭校正 7 1.3 研究目的 8 1.4 論文架構 8 第 2 章 睡眠呼吸中止症之介紹 11 2.1 口咽呼吸道構造及功能 11 2.2 睡眠多項生理檢查 13 2.3 阻塞型睡眠呼吸中止症 14 2.4 治療方式 17 第 3 章 3D列印相關理論與影像處理方法 18 3.1 3D列印技術 18 3.1.1 FDM(熱熔融層積)技術及應用 19 3.1.2 SLA(光固化)技術及應用 20 3.1.3 SLS(雷射粉末燒結)技術及應用 21 3.2 目標圈取 22 3.3 形態學 23 3.3.1 膨脹運算 23 3.3.2 侵蝕運算 24 3.4 面積計算 24 3.4.1 像素個數估算面積法 24 3.4.2 Bwarea估算面積法 24 3.5 醫學指標分析方法 27 第 4 章 實驗與驗證 31 4.1 硬體架構 31 4.1.1 雷射規格 33 4.1.2 柱狀光柵板 34 4.1.3 影像擷取裝置與電腦硬體設備 36 4.1.4 雷射投影模組製作 37 4.2 影像處理流程 39 4.2.1 鏡頭校正 39 4.2.2 過濾面積雜訊 45 4.2.3 量化方法 46 4.2.4 內視鏡影像處理及分析 54 第 5 章 實驗結果 57 5.1 臨床收案結果 58 5.1.1 正常口咽生理數值比較 58 5.1.2 阻塞型睡眠呼吸中止症口咽生理數值量化 60 第 6 章 結論 64 6.1 阻塞型睡眠呼吸中止症判定指標 66 6.2 未來發展 69 參考文獻 70 附錄(一): 國防醫學院三軍總醫院人體試驗同意函 78 附錄(二): 臨床收案樣本 79

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