本研究以聚二甲基矽氧烷(Polydimethylsiloxane, PDMS)作為基材，與異佛爾酮二異氰酸酯(Isophorone diisocyanate, IPDI)、聚(乙二醇)甲基丙烯酸酯(PEGMA)及甲基丙烯酸-2-羥基乙酯(2-hydroxy-ethyl methacrylate, HEMA)進行聚合反應，合成PDMS-IPDI-PEGMA-HEMA矽水膠共聚物，再加入不同比例之HEMA至PDMS-IPDI-PEGMA-HEMA矽水膠共聚物，使其形成新型態的矽水膠共聚物，以紫外光硬化交聯處理形成矽水膠隱形眼鏡薄膜，並探討加入不同比例的HEMA之物性分析及生物相容性測試，透過含水量量測結果顯示加入HEMA後之矽水膠隱形眼鏡有明顯的改善其含水量特性，並且於細胞毒性試驗結果顯示出良好的細胞相對成長率，根據上述結果，PDMS-IPDI-PEGMA-HEMA經由混摻HEMA後，具有良好的含水量，且對於生物細胞不具有毒性，未來對於隱形眼鏡材料的應用具有良好的潛力。

In this study, polydimethylsiloxane (PDMS) was used as the base material, combined with isophorone diisocyanate (IPDI), poly(ethylene glycol) methacrylate (PEGMA) and 2-hydroxy-ethyl methacrylate (HEMA), was polymerized to synthesize PDMS-IPDI-PEGMA-HEMA silicone rubber copolymer, and then different proportions of HEMA were added to PDMS-IPDI-PEGMA-HEMA followed by curing and cross-linking under ultraviolet light to form a silicone gel contact lens film. The effect on the physical properties and biocompatibility of adding different proportions of HEMA were discussed. The results show that the silicone hydrogel contact lens after adding HEMA has significantly improved its water content characteristics, and the cytotoxicity test results showed a good relative cell growth rate. According to the above results, after being mixed with HEMA, PDMS-IPDI-PEGMA-HEMA exhibited good water content and non-cytotoxic to biological cells. Thus, it has good potential for the application of contact lens materials in the future.

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