根據「臺灣糖尿病年鑑2019」指出，我國罹患糖尿病人數以每年16萬人增加中，其中絕大多數是第2型糖尿病，且臺灣慢性腎臟病人口密度高達11.9%，僅次於日本與美國，而洗腎人口密度已達世界第一；雖然現代醫療進步，可以倚靠血液透析的方法延續生命，然而腎病支出已造成健保沉重負擔，2020年的整體醫療費是562億元，而用於末期腎病患者進行洗腎的經費就佔84%。
為使得大眾能方便且快速判斷可能罹患的腎臟病，大多使用尿液試紙來測量，其方法雖簡單但因試紙有半定量的緣故、且判斷結果會因主觀條件與客觀條件造成差異；因此，本論文目標為將基於微機電系統(Micro-Electromechanical Systems，MEMS)技術製程的微型光譜儀用於尿液常規的多重項目量測，且能精確定量該量測項目物質的多寡。
在本論文中，以微型光譜儀作為量測系統，對尿液試紙的十二項目 1. Leukocytes (白血球酯酶)；2. Nitrite (亞硝酸鹽)；3. Urobilinogen (尿膽素原)；4. Protein (尿蛋白)；5. pH (酸鹼值)；6. Occult Blood (潛血)；7. Specific Gravity (比重)；8. Ketone (尿酮)；9. Bilirubin (尿膽紅素)；10. Glucose (葡萄糖)；11. Microalbumin (微白蛋白)；12. Creatinine (肌酸酐) 進行量測。結果證實利用微型光譜儀在各檢測項目中檢量線的決定係數R^2皆有0.95以上，因此可證實微型光譜儀用於尿液常規多重項目的可行性，且量測結果在水準之上。
透過微型尿液檢測平台，不僅省去使用大型檢測機器成本、時間與空間，也讓操作更加簡便，更使得量測場域從大型檢驗所轉變到辦公室、診所、居家、甚至是救護車上，實現定點照護檢驗(Point of Care Testing，POCT)成效，且對於未來新增其他檢體的量測研究都有顯著的提升。

According to the "Taiwan Diabetes Yearbook 2019", the number of diabetic patients in Taiwan is increasing by 160,000 each year, and most of the patients have type 2 diabetes. Reaching the first place in the world, the population density of chronic kidney disease in Taiwan is as high as 11.9%, which is second only to Japan and the United States; although the latest medical advances have made it possible to extend life by relying on hemodialysis, the expenditure on kidney disease has caused a heavy burden on health insurance. The overall medical expenses in 2020 were 56.2 billion dollars, 84% of which were spent on dialysis for patients with end-stage renal disease.
　　In order to enable the public to determine possible kidney diseases easily and quickly, most of the urine test strips are used to measure the kidney disease. Although the method is simple, the fact that the nature of test paper is semi-quantitative and the judgmental results will be different due to subjective and objective conditions. Consequently, the objective of this paper is to accurately quantify the number of substances in the measurement item by applying the MEMS-based technology to the routine multiple-item measurement of urine.
　　In this paper, the micro-spectrometer is used as a measurement system for 12 items of urine test strips. The measurement items include 1. Leukocytes; 2. Nitrite; 3. Urobilinogen; 4. Protein; 5. pH; 6. Occult blood; 7. Specific Gravity; 8. Ketone; 9. Bilirubin; 10. Glucose; 11. Microalbumin; 12. Creatinine. The results confirmed that the coefficient of determination (R^2) was more than 0.95 in the calibration curves for each detection item by using the micro-spectrometer, and thus the feasibility of using the micro-spectrometer for routine multiple items of urine is verified, and the measurement results are above the standard.
　　The micro urine testing platform not only eliminates the cost, time, and space of using large testing machines but also makes the operation more convenient. Furthermore, it allows the measurement area to change from large testing laboratories to offices, clinics, homes, and even ambulances, realizing the effectiveness of POCT while significantly improving the measurement study on other new specimens in the future.

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