碳量子點 (CQDs) 是一種新穎的碳奈米材料，由於其良好的生物相容性、簡易合成方法、細胞內優異的化學穩定性、尺寸小和高光致發光效應等優點，因此在近二十年來受到極大的關注。現今釋放過程常出現無標靶性行為，因此設計出含有標靶性抗癌藥物的CQDs為一大挑戰。本研究以銅、氮和硫摻雜的碳量子點與葡萄糖氧化酶 (GOx) 和喜樹鹼和硫縮酮連接複合物 (TLCPT) 接合形成多功能奈米催化劑 (CuCGC)，此催化劑具有強藍光致發光效應及最高量子產率90.1% 並增強催化（類過氧化物酶）活性。此外，CuCGC 奈米催化劑在產生活性氧 (ROS)方面表現出良好的性能，特別是羥基自由基 (•OH)，最大反應速率達 51.058 μM/s。除了化學動力療法 (CDT) 性能外，CuCGC 奈米催化劑在腫瘤微環境中還具有氣體療法 (GT)、飢餓療法 (ST) 和活性氧 (ROS) 響應性化學療法，且於體外實驗中可證明在微腫瘤環境中有效提高CDT效果。此外， CuCGC 奈米催化劑具有作為化學和化學動力學試劑、氣體療法和飢餓誘導劑的協同癌症治療潛力。期望 CuCGC 奈米催化劑可應用在未來臨床治療。

Carbon quantum dots (CQDs), a novel class of carbon-based nanomaterials, have received tremendous attention over the last two decades due to their superior biocompatibility, ease of fabrication, long-term chemical stability in the living cell, small size, and high photoluminescence effect. However, designing on-demand specific anticancer drugs facilitated with CQDs remains a massive challenge due to some off-target behavior during the delivery time. Here, we report copper, nitrogen, and sulfur-doped carbon quantum dots incorporated with glucose oxidase (GOx) and the thioketal linker camptothecin (TLCPT) to form a multifunctional nanocatalyst (CuCGC) that displays strong blue photoluminescence effect with the highest quantum yield reach 90.1% and enhanced catalytic (peroxidase-like) activity. Additionally, the CuCGC shows better performance in generating reactive oxygen species (ROS), specifically hydroxyl radicals (•OH), with a maximum reaction rate of 51.058 μM/s. Besides the CDT performance, CuCGC nanocatalyst also possesses gas therapy (GT), starvation therapy (ST), and reactive oxygen species (ROS) responsive chemotherapeutics in the tumor microenvironment that elevate the chemodynamic therapy (CDT) effect via systematic in vitro studies at the intracellular level. Through extensive in vitro investigations at the intracellular level, this study indicates the potential of CuCGC nanocatalyst to act as chemo- and chemodynamic agents, gas therapy, and starvation-inducing agents for collaborative cancer therapy. We anticipate that CuCGC nanocatalyst might provide a potential therapeutic candidate in future clinical applications.

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