光動力治療(Photodynamic Therapy, PDT)是利用腫瘤組織選擇性攝取及累積光敏劑後，在激發光源的驅動下發生光動力效應並產生活性氧，進而透過直接氧化殺死腫瘤細胞、破壞腫瘤微血管導致腫瘤壞死、激發免疫反應或誘導腫瘤細胞凋亡。PDT為膽管癌治療的一種新方法，並已經由臨床研究及應用過程證實其療效。對於不可進行手術切除的腫瘤患者，無論是單獨使用PDT進行治療或是與支架置入聯合應用，都可以顯著延長患者的壽命，並有效改善局部膽道阻塞症狀，提高患者生活的品質。
本研究目標為開發出一個創新的光動力膽管支架系統，此系統在未來可獨立以光動力方式進行膽管癌的治療。本研究先以細胞存活率實驗探討藍光發光二極體及紅光發光二極體光源對光動力治療效果的影響，以便選擇合適的二極體光源進行光動力膽管支架的光源系統設計。接著使用3D電腦輔助設計軟體Pro/Engineer及Solid Works開發設計光動力膽管支架及其所需的可撓性light bar。所設計的可撓性light bar上有30顆發光二極體做為光源。再利用商業光學模擬軟體Trace Pro模擬以整合所設計light bar的光動力支架進行光動力治療時的照度分布及劑量計算。最後，本研究建構所設計的光動力支架光源系統並進行實驗及量測，並以實驗結果驗證所建立模擬模式的正確性。

Photodynamic therapy (PDT) uses the selective uptake and collect functions of photosensitizer in tumor. Reactive oxygen is generated because of the photodynamic action acting by excitation light source. With this kind of reaction, the tumor cells can be destroyed by oxidize, destroying tumor by damaging tumor microvascular, excitation immune response or inducing tumor apoptosis. The application of PDT in novel cholangiocarcinoma treatment is approved by clinical research and practical application. To the patient who cannot remove the tumor by traditional surgery, both the direct use of PDT and multiple application of stenting with PDT can improve the symptom of partial biliary obstruction and extend patient’s life significantly.
In this study, we developed an illumination system for an innovative photodynamic biliary stent which is able to perform photodynamic curative treatment for cholangiocarcinoma in the future. Experiments of cell viability were carried out to study the light source effect in order to choose an appropriate light source for our system. 3D CAD software (Pro/Engineer and SolidWorks) was used to develop the design of photodynamic biliary stent and flexible light bar, which is with 30 light emitting diodes and used as the light source of the stent. Commercial optical simulation software TracePro was applied to simulate the illumination performance of the designed light bar and photodynamic stent. Finally, experiments with the developed illumination system for photodynamic stent were performed and the results were used to validate the simulation model.

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