隨著3C產品日益發展，許多研究顯示過量的藍光會對角膜、晶狀體和視網膜造成不同程度的損傷，因此，如何抵擋藍光成為現今重要的議題，為了減少藍光對人體傷害，抗藍光產品越來越受到重視。本研究以端羥基聚二甲基矽氧烷(Hydroxyl-terminated polydimethylsiloxane, PDMS-diol)作為基材，與異佛爾酮二異氰酸酯(Isophorone diisoctanate, IPDI)以及聚乙二醇甲基丙烯酸酯(polyethylene glycol methacrylate, PEGMA)進行聚合反應，合成PDMS-PU macromer，加入N-乙烯基-2-吡咯烷酮(N-Vinylpyrrolidone, NVP)親水性單體形成矽水膠共聚物，再藉由紫外光硬化處理形成三維網狀結構之矽水膠共聚物。所得之矽水膠樣品，再以不同濃度之Reactive yellow 86 (RY86)水溶液，經由表面染色法來達到抗藍光效果，並探討具有不同含量之RY86矽水膠樣品其物性分析與生物相容性測試。結果顯示，隨著RY86含量增加其抗藍光效果也隨之增加，全段藍光波段(380-500nm)之穿透率下降約42%，部分藍光波段(415-455nm)之穿透率下降約60%，具有良好的抗藍光效果。研究結果顯示，RY86矽水膠具有良好的生物相容性與生物細胞無毒性，同時具有良好的透氧性以及親水性，未來對於功能性隱形眼鏡材料具有良好發展與應用。

In this study, hydroxyl-terminated polydimethylsiloxane (PDMS-diol) was used as the base material, reacted with isophorone diisocyanate (IPDI) and polyethylene glycol methacrylate (PEGMA) to synthesize PDMS-PU macromer, and then add N-vinyl-2-pyrrolidone (NVP) to form a silicone hydrogel copolymer. After curing with ultraviolet light, the silicone hydrogel copolymer forms a three-dimensional network. The resultant silicone hydrogels were then dyed with reactive yellow 86 (RY86) to block blue light. The physical properties and the biocompatibilities of these RY86-dyed silicone hydrogels were investigated. According to the result of UV-Vis spectrophotometer analysis, it was confirmed that as the content of the blue light absorbers increases, the blocking strength against blue light also increases. The transmittance in the blue light wavelength region between 380 and 500nm is reduced by about 42%. In addition, the transmittance in the blue light wavelength region between 415 and 455nm is reduced by about 60%. It shows that the sample has good anti-blue light effect. The results show that RY86 can confer silicone hydrogel with suitable biocompatibility and non-cytotoxicity without reducing oxygen permeability and hydrophilicity. Therefore, this approach would be applicable for functional contact lenses.

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