此研究依醫學影像分析顯影科技發展方向，主要來作為開發雙功能顯影劑上的材料開發及結合核磁影像與光學造影技術的生物應用。此研究以I-III-VI族半導體材料作為材料主軸，分別以主要進行針對銀銦化硫AgInS2量子點進行最適化量子產率研究及CuInS2量子點及氧化鐵磁性顆粒的多功能顯影二氧化矽複合物合成、鑑定與應用。

第一部分:主要進行提高銀銦化硫I-III-VI族量子點的量子產率為目的，並期許能夠開發較高量子產率、綠色環保及無毒性半導體材料，應用於光電材料或生物醫學科技。在AgInS2量子點的合成研究中，經實驗設計，我們主要藉由加入硫醇來抑制I族(Ag)與硫元素的反應活性及使用硬酯酸銦來提升III族(In)與硫的反應活性，平衡I族與III族元素與硫元素的反應性達到理想點，使在成核反應時可以產生高量子產率晶體。在參數調整方面，我們以主要改變前驅物比例作參數調整。在一系列的最佳化量子產率，可以知道在前驅物的特定比例，反應溫度150℃下，60分鐘可獲得10 %左右的量子產率。

第二部分:利用二氧化矽來進行I-III-VI族量子點及磁性顆粒的表面改質，形成二氧化矽奈米複合物，並且提升溶解度及使之官能化，利用胺基矽烷及聚乙氧烯矽氧烷作表面修飾分別提供官能基鍵結和生物相容性，最後功能化複合物，特異性鍵結抗癌藥物，成功開發多功能顯影劑，並且針對此複合物光學、磁性及表面鑑定，確認此構想，能夠符合期待。在應用研究上，為了符合多功能的的顯影劑目的，我們分別利用此複合物進行MCF-7乳癌細胞的光學造影實驗及核磁共振造影MRI的T2影像測試。

In this research, we developed engineering of multifunctional nanohybrids for biomedical imaging techniques including magnetic resonance imaging and confocal microscopy. We selected I-III-VI group materials as our targets and have two parts of experiment in this research.

In the first purpose, we enhance quantum yield of AgInS2 quantum dots (QDs) by hot-injection method. Following the design of experiment, by using precursors and surfactant thiol as our experiment parameters to balance the reactivity of I group and III group element with surfactant thiol for developing the high-quality AgInS2 QDs. Finally, we get ~10 % quantum yield via optimizing the temperature and the ratios of Ag/In precursors, and surfactant thiol.

Second, we successfully proposed a reliable method for producing multifunctional silica nanohybrids, entrapping fluorescent and superparamagnetic nanoparticles (NPs), as well as anticancer drug. This studies including three parts: (1) synthetic optimization of CuInS2/ZnS QDs, characterized by UV-Vis, PL, TEM and XRD, (2) the preparation of multifunctional silica nanohybrids consisting of CuInS2/ZnS QDs and Fe3O4 magnetic NPs by a reverse micro-emulsion method, and (3) anticancer drugs immobilized on the surface silica nanohybrids. As a consequence of these distinct properties, a combination of fluorescent and magnetic properties in one silica nanohybrids enables simultaneous biolabeling and　magnetic resonance imaging.

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