現今普遍治療雄性禿（androgenetic alopecia）的方法包括口服柔沛（finasteride）、外用生髮水（minoxidil）與植髮（hair transplantation），但這些方法的成效各有所限制。近年經學者研究發現，在體外使毛囊真皮乳頭細胞（dermal papilla cells）大量增生，再將真皮乳頭細胞團植入禿髮處，便可誘導毛囊新生。但現階段的植入方式為採用手術或注射器等方式置入細胞團，須耗費大量時間在製備及裝填細胞團的步驟。為了縮短前置作業時間、加快植入速度與固定植入深度，本研究開發具有細胞儲存能力的連續式細胞團植入器。
連續式植入器的概念是將半固體狀的真皮乳頭細胞團放入「彈匣」中或直接於「彈匣」中進行培養，再利用各器械的自動進給機制推送植入體透過針具進行植入。植入器械的設計包括自動撐開式、條狀彈匣式與轉盤彈匣式三種，設計完成後利用3D繪圖軟體繪製零件並以快速原型技術製作出原型零件，再將零件與針具結合組裝後，進行多項實驗比較各植入器的特性；並利用染色洋菜膠作為模擬植入體打入豬皮，切片後以放大鏡觀察其植入效果與植入深度並進行評估。測試結果發現轉盤彈匣式具有高容量彈匣及相對舒適的操作方式，自動撐開式則具有刺入皮膚、撐開、推出與切斷植入體的功能，可減少對植入體擠壓的機會，但就現階段實驗結果來說，具有良好植入效果及速度的條狀彈匣式是目前可行性較高且較適合進行細胞團植入的設計。

Finasteride, minoxidil, and hair transplantation are the popular ways to treat androgenetic alopecia, but each has its limited effects. The recent study found that implanting massively in-vitro proliferated dermal papilla cells into the bald areas could induce the transdifferentiation of epidermis into hair follicles. However, the existing approaches to implant the cell aggregates are by surgery or by syringe, requiring a lot of time on preparation and loading the cells. In order to shorten the preparation time, accelerate implant speed and control implanted depth, this research developed continuous implanters which have cell storage capability.
The concept of continuous implanter is to place semi-solid dermal papilla cells or cultivate them directly in a cartridge, and an auto-feed mechanism is utilized to push the cells into the derma through a needle. Three designs were investigated—auto-expand type, bar-cartridge type, and rotary-cartridge type. The implanters were designed in 3D CAD software and fabricated their prototypes by rapid prototyping techniques. After assembly of the components and the needles, several tests were conducted to compare the characteristics of the three designs. Moreover, dyed agar was used to simulate the cell aggregates implanting into porcine derma. The implanted biopsy samples were observed by a microscope. The results revealed that the rotary-cartridge type had advantages of high storage capacity and relatively comfortable operation, while the auto-expand type contained functions of penetrating the skin, expanding the cut, and pushing and cutting off the cell implant that would reduce the chance to squeeze the cells. The bar-cartridge type had the best performance and highest speed among the three, and is considered the most feasible and suitable design to continuously implant cell aggregates.

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