氫氧基磷灰石混摻ALG/HEMA雙網絡水凝膠之3D可列印骨修復生物材料

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研究生：	陳彥蓉 Yen-Jung Chen
論文名稱：	氫氧基磷灰石混摻ALG/HEMA雙網絡水凝膠之3D可列印骨修復生物材料 3D Printable Bone Repairing Biomaterial of ALG / HEMA Semi-Double Network Hydrogel Embedded Hydroxyapatite
指導教授：	今榮東洋子 Toyoko Imae
口試委員:	氏原真樹 Masaki Ujihara 陳崇賢 Chorng-Shyan Chern
學位類別：	碩士 Master
系所名稱：	工程學院 - 化學工程系 Department of Chemical Engineering
論文出版年：	2019
畢業學年度：	107
語文別：	英文
論文頁數：	53
中文關鍵詞：	氫氧基磷灰石、3D列印、雙網絡水凝膠、海藻酸鈉、骨修復生物材料
外文關鍵詞：	Hydroxyethylmethacrylate, Semi-double network, Bone repairing biomaterial, Stereolithographic 3D Printing
相關次數：	點閱：301 下載：0
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此研究發表一個由氫氧基磷灰石(HAp)均勻分散於甲基丙烯酸羟乙酯(HEMA)、乙二醇二甲基丙烯酸酯(EGDMA)、海藻酸鈉(ALG)混合水溶液所組成的新型半雙網絡水凝膠(S-DN)骨修復生物材料。該材料之機械性質、含水量、收縮度與形態學皆被調查。在這之中，ALG/HEMA-HAp 10%乾凝膠顯示出高達16.378MPa的拉伸應力，且其伸長度為4.61%，可相當於人體小梁骨的機械性質。最終我們添加Irgacure 127 1.00wt%和Kemisorp 11S 0.04 wt%，使用光固化3D列印機SWIM-ER成功列印出3D立體骨頭造型ALG/HEMA-HAp。

A new bone repairing biomaterial, ALG/HEMA-HAp, was a semi-double network (S-DN) hydrogel fabricated from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) in the aqueous mixed dispersion of hydroxyapatite (HAp) and sodium alginate (ALG). The mechanical properties, moisture, shrinkage and morphology of all samples were investigated. Among them, The ALG/HEMA-HAp 10% xerogel showed the stress is 16.378 MPa and the elongation is 4.61%, which might be comparable to the human’s trabecular having the tensile strength of 10 to 20 MPa and elongation of 5% to 7%. Finally, we use Stereolithographic 3D Printer SWIM-ER, and then succeed to print out a 3D bone shape after adding Irgacure 127 1.00wt% and Kemisorp 11S 0.04 wt%.

Abstract i
Table of contents ii
List of figures v
List of tables vii

Chapter 1 INTRODUCTION 1
1 Bone Regeneration Engineering 1
1.1 Development of Bone Regeneration Medicine 2
1.2 Human’s Bone 2
1.2.1 Composition of Bones 2
1.2.2 Structures of Bones 3
1.2.3 Mechanical properties of Bones 4
2 Bone Repair Biomaterials 5
2.1 Design concept for Bone scaffolds 5
2.2 Metallic Scaffolds 5
2.3 Polymeric Scaffolds 6
2.3.1 Natural polymers 6
2.3.2 Synthetic polymers 7
2.4 Ceramic Scaffolds 7
3 Semi-Double Network (S-DN) hydrogel 8
3.1 Interpenetrating Polymer Network (IPN) 8
3.2 Semi-Double Network Bone Scaffold Design 9

Chapter 2 EXPERIMENTAL 10
1 Materials and Instruments 10
1.1 Reagents 10
1.2 Instruments 10
2 Precursor Solution Preparation 13
2.1 ALG − HAp composite films 13
2.2 HEMA hydrogels/xerogels 13
2.3 ALG/HEMA − HAp hydrogels/xerogels 14
2.4 ALG/HEMA – HAp Precursor Solution for Stereolithographic 3D Printing 14
3 Stereolithographic 3D Printing 15
3.1 Printing Speed Text 15
3.2 Printing Process of 2D and 3D 15

Chapter 3 RESULTS AND DISCUSSION 17
1 Phase Separation Problem 17
1.1 The Maximum content of ALG 17
1.2 The Maximum content of HAp 18
1.3 The best ratio between HEMA and H2O 19
1.4 Initiator 20
2 Mechanical Properties and Morphological Examination 21
2.1 Effect of Semi-Double Network to Mechanical Properties 21
2.2 Effect of HAp content to Mechanical Properties 23
2.3 Effect of EGDMA content to Mechanical Properties 28
3 Moisture and Shrinkage 32
3.1 Effect of HAp content to Moisture and Shrinkage 32
3.2 Effect of EGDMA content to Moisture and Shrinkage 33
4 Stereolithographic 3D Printing 34
4.1 Printing Speed Text 34
4.2 3D Printing for ALG/HEMA – HAp hydrogel 35
4.3 Shrinkage of 3D printing Bone Shape 36

Chapter 4 CONCLUSIONS 37
References 38
Appendix – Presentation Award 42


                                

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全文公開日期 2024/08/16 (校內網路)
全文公開日期 2024/08/16 (校外網路)
全文公開日期 2024/08/16 (國家圖書館：臺灣博碩士論文系統)

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