研究生: |
Thirayu Chuesutham Thirayu Chuesutham |
---|---|
論文名稱: |
藻酸鹽,碳點和磁鐵礦複合材料的製程以及多種應用 Synthesis of alginate combining carbon dots coated magnetite for multiple therapy |
指導教授: |
今榮東洋子
Toyoko Imae |
口試委員: |
氏原真樹
Masaki Ujihara 高震宇 Chen-Yu Kao |
學位類別: |
碩士 Master |
系所名稱: |
應用科技學院 - 應用科技研究所 Graduate Institute of Applied Science and Technology |
論文出版年: | 2018 |
畢業學年度: | 106 |
語文別: | 英文 |
論文頁數: | 47 |
中文關鍵詞: | 藻酸鹽 、碳點 、氧化鐵 |
外文關鍵詞: | Alginate, Carbon dots, Magnetite(Fe3O4) |
相關次數: | 點閱:270 下載:0 |
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具有奈米碳點(Cdot)在四氧化三鐵(Fe3O4)的表面與藻酸鹽(alginate)結合的奈米凝膠(Alg-Fe3O4@C)具有無毒性、高生物相容性、優異的光穩定性和良好的水分散性,適用於多種療法,如藥物傳輸,磁共振成像(MRI)以及溫熱療法。 通過奈米碳點塗覆在Fe3O4奈米顆粒,然後通過使用1-乙基-3-(3-二甲基氨基丙基)碳二亞胺(1-Ethyl-3-(3-dimethylaminopropyl)carbodimide)和N-羥基琥珀酰亞胺(N-Hydroxysuccinimide)作為酰胺化反應的偶聯劑將Fe3O4@C 與藻酸鹽作結合。 使用傅立葉變換紅外吸收光譜分析(FTIR),動態光散射儀(DLS,SZ-100),和透射電子顯微鏡(TEM)分析來研究Alg-Fe3O4 @ C的表面特徵。而在藥物乘載與藥物釋放方面,比起藻酸鹽,Alg-Fe3O4@C 具有較佳的表現。
Nanogels based on alginate combining carbon dots-coated magnetite (Alg-Fe3O4@C) with nontoxicity, high biocompatibility, excellent photo-stability, and good water dispersibility were synthesized for applications to multiple therapies like drug delivery, MRI contrast and hyperthermia. Fe3O4 nanoparticles were coated by carbon dots (Fe3O4@C), then combined with alginate by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS) as coupling agents of amidation reaction. The characterizations of (Alg-Fe3O4@C) were investigated using fourier transform infrared (FTIR) absorption spectroscopic analysis, dynamic light scattering instrument (DLS, SZ-100), zeta-potential and transmission electron microscopic (TEM) analysis. Loading and release of doxorubicin on the nanogels were larger than alginate nanogel.
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