簡易檢索 / 詳目顯示

研究生: 陳佳平
Chia-Ping Chen
論文名稱: 以貝式網路為基礎建立模型預測肺癌病人的醫療費用與存活時間
Predicting medical expenditure and survivability of the lung cancer patient by Bayesian network
指導教授: 王孔政
Kung-Jeng Wang
口試委員: 林希偉
Shi-Woei Lin
鄧乃嘉
Teng Nai-Chia
學位類別: 碩士
Master
系所名稱: 管理學院 - 工業管理系
Department of Industrial Management
論文出版年: 2016
畢業學年度: 104
語文別: 英文
論文頁數: 64
中文關鍵詞: 高斯貝式網路肺癌醫療費用存活時間
外文關鍵詞: Conditional Gaussian Bayesian network, lung cancer, medical expenditure, survivability
相關次數: 點閱:243下載:7
分享至:
查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報
  • 肺癌是導致死亡的主要因素,高斯貝式網路建立預測肺癌病人的存活時間和醫療支出,本研究使用健保局資料庫,且模型不僅考慮慢性疾病和治療影響,也提供存活時間和費用的機率密度函數,存活時間和費用的模型預測能力的調整R2也提升到80.37%和40.35%。


    Lung cancer leads to a major cause of death. This study presents a Conditional Gaussian Bayesian network to predict survival time and medical expenditure of the lung cancer patient. This study uses the subject data in National Health Insurance Research Database from 1995 to 2010. The model considers chronic diseases and treatment effect and provides the density function of survival time and expenditure. The prediction of survival time and expenditure is promising with adjust R2 of 80.37% and 40.35%.

    Contents 摘要 I Abstract II 致謝 III Content of Figure V Content of Table VI Chapter1 Introduction 1 1.1 Research background 1 1.2 Research motivation 2 1.3 Research objective 3 1.4 Research limitation 3 1.5 Thesis structure 4 Chapter2 Literature 5 2.1 Risk adjustment 5 2.2 The risk factor of lung cancer 9 2.3 Bayesian network 10 Chapter3 Model 12 3.1 Bayesian network 12 3.2 Variable 12 3.3 Graphical modelling 16 Chapter4 Materials and results 19 Chapter5 Result and discussion 22 Chapter6 Conclusion 41 References 42 Appendix A: Variables definition 46 Appendix B: Medical expenditure 47 Appendix C: Resulting conditional probability table of site 48 Appendix D: The probability of backstopping of survival time 50 Appendix E: The performance of adjusted-R2 of survival time 52 Appendix F: Resulting conditional probability table of site 52 Appendix G: The probability of backstopping of expenditure 54 Appendix H: The performance of adjusted-R2 of future expenditure 56

    American Surveillance Epidemiology and End Results. (2010). SEER Stat Sheets: Lung and Bronchus Cancer. Retrieved from http://seer.cancer.gov/statfacts/html/lungb.html
    Bttcher, S. G., & Dethlefsen, C. (2003). Deal: A Package for Learning Bayesian Networks. Journal of Statistical Software, 8(20), pp. 1-40. Retrieved from Deal: A package for learning bayesian networks.
    Brown, J. S., Eraut, D., Trask, C., & Davison, A. G. (1996). Age and the treatment of lung cancer. Thorax, 51(6), 564-568.
    Chang, H.-Y. (2009). Evaluation of Alternative Diagnosis-based Risk Adjustment Models and Morbidity Trajectories for Application in Taiwan. Baltimore: The Johns Hopkins University.
    Chang, R.-E., & Lai, C.-L. (2004). Risk Adjuster: the Basis for Capitation Payment. Taiwan Journal of Public Health, 23(2), pp. 91-99.
    Chang, R.-E., Lin, W., Hsieh, C.-J., & Chiang, T.-L. (2002). Healthcare Utilization Patterns and Risk Adjustment Under Taiwan's National Health Insurance System. Journal of the Formosan Medical Associatio, 101(1), 52-59.
    Cheng, T.-M. (2015). Taiwan’s Health Care System: The Next 20 years. Taiwan-U.S. Quarterly Analysis(17). Retrieved from http://www.brookings.edu/research/opinions/2015/05/14-taiwan-national-healthcare-cheng
    Cobb, B. R., Rumi, R., & Salmeron, A. (2007). Bayesian Network Models with Discrete and Continuous Variables. Advances in Probabilistic Graphical Models, Studies in Fuzziness and Soft Computing, 214, pp. 81-102.
    Cucciare, M. A., & O’Donohue, W. (2006). Predicting Future Healthcare Cost: How Well does Risk-Adjustment Work? Journal of Health Organization and Management, 20(2), pp. 150-162.
    Ferlay, J., Soerjomataram, I., Ervik, M., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D. & Bray, F. (2014). Cancer Incidence and Mortality Worldwide: Sources, Methods and Major Patterns in GLOBOCAM 2012. International Journal of Cancer, 136(5), pp. 359-386.
    Fry, W. A., Phillips, J. L., & Menck, H. R. (1999). Ten‐year survey of lung cancer treatment and survival in hospitals in the United States. Cancer, 86(9), 1867-1876.
    Fuch, V. R. (1968). The Growing Demand for Medical Care. The New England Journal of Medicine, 279, pp. 190-195.
    Greenberg, E. R., Chute, C. G., Stukel, T., Baron, J. A., Freeman, D. H., Yates, J., & Korson, R. (1988). Social and economic factors in the choice of lung cancer treatment. New England Journal of Medicine, 318(10), 612-617.
    Health Promotion Administration, Ministry of Health and Welfare. (2014). 2014 Health Promotion Administration Annual Report. Taipei: Health Promotion Administration, Ministry of Health and Welfare.
    Jaakkimainen, L., Goodwin, P. J., Pater, J., Warde, P., Murray, N., & Rapp, E. (1990). Counting the costs of chemotherapy in a National Cancer Institute of Canada randomized trial in nonsmall-cell lung cancer. Journal of Clinical Oncology, 8(8), 1301-1309.
    Jemal, A., Center, M. M., DeSantis, C., & Ward, E. M. (2010). Global Patterns of Cancer Incidence and Mortality Rates and Trends. Cancer Epidemiology, Biomarkers & Prevention, 19(8), pp. 1893-1907.
    Jensen, F. V. (1996). Introduction to Bayeisan Network. Berlin: Springer.
    Ko, Y.-C., Lee, C.-H., Chen, M.-J., Huang, C.-C., Chang, W.-Y., Lin, H.-J., Wang, H.-Z., & Chang, P.-Y. (1997). Risk factors for primary lung cancer among non-smoking women in Taiwan. International Journal of Epidemiology, 26(1), pp. 24-31.
    Lang, H.-C., & Wu, S.-L. (2012). Lifetime Costs of the Top Five Cancers in Taiwan. The European Journal of Health Economics, 13(3), pp. 347-353.
    Lauritzen, S. L. (1992). Propagation of Probabilities, Means, and Variances in Mixed Graphical Association Models. Journal of the American Statistical Association, 87(420), pp. 1098-1108.
    Li, T.-Y., Hsieh, J.-S., Lee, K.-T., Hou, M.-F., Wu, C.-L., Kao, H.-Y., & Shi, H.-Y. (2014). Cost Trend Analysis of Initial Cancer Treatment in Taiwan. PLoS ONE, 9(10), pp. 1-11.
    Lucas, P. J., van der Gaaq, L. C., & Abu-Hanna, A. (2004). Bayesian Networks in Biomedicine and Health-Care. Artificial Intelligence in Medicine, 30(3), pp. 201-214.
    Mahadevia, P. J., Fleisher, L. A., Frick, K. D., Eng, J., Goodman, S. N., & Powe, N. R. (2003). Lung cancer screening with helical computed tomography in older adult smokers: a decision and cost-effectiveness analysis. Jama, 289(3), 313-322.
    Ministy of Health and Welfare. (2015). Ministy of Health and Welfare, National Health Insurance Administration. Retrieved from Ministy of Health and Welfare, National Health Insurance Administration: http://www.nhi.gov.tw/webdata/webdata.aspx?menu=18&menu_id=683&webdata_id=444
    Rosell, R., Gomez-Codina, J., Camps, C., Maestre, J., Padille, J., Canto, A., ... & Canela, M. (1994). A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer. New England Journal of Medicine, 330(3), 153-158.
    Roth, J. A., Atkinson, E. N., Fossella, F., Komaki, R., Ryan, M. B., Putnam, J. B., ... & Hong, W. K. (1998). Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer. Lung cancer,21(1), 1-6.
    Roth, J. A., Fossella, F., Komaki, R., Ryan, M. B., Putnam, J. B., Lee, J. S., ... & Atkinson, E. N. (1994). A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer. Journal of the National Cancer Institute, 86(9), 673-680.
    Samet, J. M., Tang, E. A., Boffetta, P., Hannan, L. M. , Marston, S. O., Thun, M. J., & Ruding, C. M. (2009). Lung cancer in never smokers: clinical epidemiology and environmental risk factors. Clinical Cancer Research, 15(18), pp. 5626-5645.
    Scutari, M. (2010). Learning Bayesian Networks with the bnlearn R Package. Journal of Statistical Software, 35(3), pp. 1-22.
    Scutari, M. (2015). Retrieved from bnlearn: Bayesian Network Structure Learning, Parameter Learning and Inference: http://www.bnlearn.com/
    Smit, E. F., van Meerbeeck, J. P., Lianes, P., Debruyne, C., Legrand, C., Schramel, F., ... & Neymark, N. (2003). Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non–small-cell lung cancer: A phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group—EORTC 08975.Journal of clinical oncology, 21(21), 3909-3917.
    Uusitalo, L. (2007). Advantages and Challenges of Bayesian Networks in Environmental Modelling. Ecological Modeling, 203, pp. 312-318.

    QR CODE