本研究量取二氧化碳(carbon dioxide) + 苯乙烯(styrene)、+ 聚乙二醇、+ 乙二醇單甲基醚酯、+ 乙醇(ethanol)、+ 丙酮(acetone)，與+ 喹林(quinoline)溶劑所組成之雙分系統的汽液相邊界數據，平衡溫度介於291.15 K ~ 358.15 K，操作壓力則高至約42.03 MPa或臨界壓力附近。實驗所量取的混合物相平衡數據使用Soave-Redlich-Kwong、Peng-Robinson與Patel-Teja狀態方程式，配合含單交互作用參數之凡得瓦爾單一流體混合律 (MR-Q1) 與雙交互作用參數之凡得瓦爾單一流體混合律(MR-Q2)，進行汽液相平衡的計算。將所量取的相邊界數據平滑化後，可求得在給定溫度與壓力下，共存之汽液兩相的組成，進而求得K值。在臨界區附近各成分之K值隨壓力的變化情形之相圖，有助於吾人了解臨界區附近的相行為，由於臨界點附近之熱物性資料極為缺乏，這些結果對於從事臨界區附近之熱力模式改進的研究者而言，很有參考的價值。
本研究進一步量取由二氧化碳(carbon dioxide)抗溶劑與二甲基亞砜(DMSO)/乙醇(EtOH) ＝ 7/3、二甲基亞砜(DMSO)/乙醇(EtOH) ＝ 5/5、二甲基亞砜(DMSO)/乙醇(EtOH) ＝ 3/7、氯仿(chloroform)/甲醇(MeOH) ＝ 1/2 、1-辛醇(1-octanol)/聚乙二醇(PEG-200) ＝ 9/1、乙醇(EtOH)/水(H2O) ＝ 9/1、二甲基亞砜(DMSO)/水(H2O) ＝ 9/1與二甲基甲醯胺(DMF)/水(H2O) ＝ 7.5/2.5不同莫耳分率比之混合溶劑所組成之三成份系統的恆溫汽液相邊界數據，平衡溫度介於298.15 K ~ 348.15 K，操作壓力則高至約22.87 MPa或臨界壓力附近。三成分系統使用Peng-Robinson狀態方程式配以雙交互作用參數之凡得瓦爾單一流體混合律進行汽液相邊界的估算，各交互作用參數分別先由雙成分系統之汽液平衡數據訂定。

A visual and volume-variable high-pressure phase equilibrium analyzer (PEA) was used for determining the phase boundaries over a wide pressure range, including near critical region, by a synthetic method.
The isothermal vapor-liquid phase boundaries were measured, in the present study, for CO2 (1) + styrene, CO2 (1) + polyethylene glycol-200 (2), CO2 (1) + propylene glycol methyl ether acetate (2), CO2 (1) + ethanol (2), CO2 (1) + acetone, and CO2 (1) + quinoline (2) at temperatures from (291.15 to 358.15) K and pressures up to 42.03 MPa. The new VLE data were correlated with the Soave, the Peng-Robinson (PR) and the Patel-Teja (PT) equations of state (EOS) incorporating with the one-parameter and the two-parameter van der Waals one-fluid mixing rules, respectively. On the basis of the experimental results, the isothermal K-values varying with pressure were presented graphically around the critical points. In this region, the available information is rather limited. The phase equilibrium data also provide a valuable basis for the development of new equations of state, especially for improving representation of the phase behavior near critical region.
This apparatus was further used to measure the isothermal vapor-liquid phase boundaries for CO2 + [dimethyl sulfoxide/ethanol = 7/3], CO2 + [dimethyl sulfoxide/ethanol = 5/5], CO2 + [dimethyl sulfoxide/ethanol = 3/7], CO2 + [chloroform/methanol = 1/2], CO2 + [1-octanol/polyethylene glycol-200 = 9/1], CO2 + [ethanol /H2O = 9/1], CO2 + [dimethyl sulfoxide/H2O = 9/1], and CO2 + [N,N-Dimethylformamide/H2O = 7.5/2.5] ternary systems in a temperature range from (298.15 to 348.15) K and pressures up to 22.87 MPa or critical pressures over a wide composition range. The PR EOS with the two-parameter van der Waals one-fluid mixing rules was adopted in this study to predict the phase boundaries of the ternary systems. The experimental values were compared with the predicted results from the PR EOS with the binary interaction parameters determined from the VLE data of the constituent binaries. It was found that the agreement was reasonably well. Critical point at each temperature was determined by interpolation of the experimental phase boundary. The results of this study are of importance to explore suitable operating conditions for manipulating particle formation with supercritical anti-solvent process.

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