穩定態功能性磁振造影：刺激調變與反應強度之相依性研究

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研究生：	蔡宜錄 Yi-Lu Tsai
論文名稱：	穩定態功能性磁振造影：刺激調變與反應強度之相依性研究 Functional Magnetic Resonance Imaging Using Balanced Steady-State Free Precession: a Task-Modulation-Dependence Study of Brain Functional Activation
指導教授：	黃騰毅 Teng-Yi Huang
口試委員:	蔡尚岳 Shang-Yueh Tsai 王福年 Fu-Nien Wang 林益如 Yi-Ru Lin
學位類別：	碩士 Master
系所名稱：	電資學院 - 電機工程系 Department of Electrical Engineering
論文出版年：	2009
畢業學年度：	97
語文別：	英文
論文頁數：	59
中文關鍵詞：	平面回訊影像、平衡穩定態自由旋進、血氧相依程度、血氧靈敏穩定態、功能性對比
外文關鍵詞：	EPI, TB-bSSFP, BOLD, BOSS, functional contrast
相關次數：	點閱：162 下載：2
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血氧靈敏穩定態已開始逐步應用於功能性磁振造影。該技術主要用來偵測質子頻率在穩定態自由旋進的相位圖之中，於狹窄的頻帶範圍內的相位變化，藉此產生功能性對比。血氧靈敏穩定態有別於傳統的平面回訊影像，其功能性對比具有複雜的非線性特性。以這種方式得到的功能性對比是否與平面回訊影像有著相同的反應結果，這是本論文欲深究探討的課題。我們的實驗證實：血氧靈敏穩定態在不同程度的視覺刺激之下，各自得到不同的功能性對比。相較於平面回訊影像技術，帶有更高的功能性對比。我們也進一步藉由平衡血氧靈敏穩定態與平面回訊影像之間的相關性係數得知兩種技術在不同程度的視覺刺激下，擁有高度的關聯性。

Recently, blood oxygenation sensitive steady-state (BOSS) has been applied for functional MRI. The functional contrast of BOSS depends on the complex and nonlinear phase behavior, which is quite different from the BOLD methods. Whether the functional-contrast studies using the BOLD methods and BOSS can reach the same conclusions is still not investigated. To answer this question, in our study, we designed a visual experiment to compare the stimulus-rate dependency of the functional contrast of both BOLD-EPI and BOSS. In the result, the BOSS curve shows highly correlated to the BOLD-EPI curve. Furthermore, the averaged functional contrasts obtained by BOSS are higher than that obtained by BOLD-EPI.

Chapter 1 Introduction	1
1 fMRI: BOLD and EPI	1
2 SSFP fMRI: Transition Band vs. Pass Band	3
3 Comparison between EPI and BOSS: A Stimulus-Rate Dependency Study	5
Chapter 2 Theory	6
1 Principles of EPI and Its Applications To The BOLD Study	6
1.1. Gradient-Echo EPI	6
1.2. EPI Gradients: Readout and Phase	8
1.3. EPI Artifacts	12
1.4 Application To BOLD Imaging	14
2 Balanced SSFP and Its Applications to fMRI	17
2.1 Balanced SSFP Sequence	18
2.2 Transition-Band bSSFP fMRI: Large Angle vs. Small Angle	21
2.3 Pass-Band bSSFP fMRI	25
Chapter 3 Methods and Materials	27
1 Software Packages and Other Functions	28
1.1 Psychtoolbox	28
1.2 fMRI Analysis Using SPM	29
1.2.1 SPM Introduction	29
1.2.2 Slice Timing	31
1.2.3 Image Registration	33
1.2.4 GLM Model	36
1.2.5 fMRI Time Series	39
2 Data Acquisition	42
3 Data Analysis	44
Chapter 4  Result	45
Chapter 5  Discussion	53
1 The Correction of Signals Drift	53
2 A Rate-Dependency Study of Human Visual Cortical Response	55
Reference	57

                                

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