本研究主要是以水溶性幾丁聚醣(Water-Souble Chitosan；簡稱WSC)和水性聚胺酯（Aqueous polyurethane；簡稱WPU），藉由均為水性之WPU及WSC，進行混摻以探討WPU/WSC複合之生醫特性及物性。由於合成陰離子型之水性聚胺酯時引進羧酸基團，使具有良好血液適合性；而水性聚胺酯具有彈性，幾丁聚醣在乾燥狀態則為硬與脆之特性，故藉由水性聚胺酯增加幾丁聚醣的彈性和柔軟度。經實驗證實，隨著WSC含量的增加，抗拉強度隨之提升；而隨著WPU含量的增加，伸長率也隨之提升。並藉由NaOH之調整，以評估WPU/WSC混摻之抗凝血性，實驗顯示血小板附著、蛋白質吸附，隨著WSC含量的增加，會降低血漿中的蛋白質吸附及血小板活性和黏著，並經由活化部分凝血活酶時間實驗得知，APTT會隨著WSC含量增加而呈現線性增加的趨勢，達到抗凝血之效果。

This study investigated the biomedical characteristics and physical properties of a composite material consisting of a mixture of water-soluble chitosan (WSC) and aqueous polyurethane (WPU).
Because synthetic anionic WPU acquires a carboxylic acid group, it is highly compatible with blood. While WPU is flexible, chitosan is hard and brittle when in a dry state. As a consequence, aqueous polyurethane can be used to give flexibility and softness to chitosan. Our experiments verified that increasing WSC content causes the tensile strength of the WSC/WPU mixture to increase. And elongation increases with WPU content. We also varied the amount of NaOH used to assess the anticoagulant properties of the WPU/WSC mixture. Our experimental results showed that platelet adhesion and protein adsorption increased with WSC content. The mixture can therefore reduce plasma protein absorption and platelet activity and adhesion. An activated partial thromboplastin time test (APPT) showed that APTT increases in a linear fashion, exerting an anticoagulant effect, with increasing WSC content.

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