由於高科技產業對經濟發展相當重要，高科技廠房耐震設計較一般建築結構標準更嚴格，因為廠房內放置許多精密儀器，對任何微小振動皆相當敏感而可能造成損壞，因此，本研究期望能適當模擬高科技廠房結構實際受震反應，提供耐震設計上可靠的參考依據。
本文探討五層樓建築於水平地震作用下，考慮水平向、翻轉向以及水平與翻轉偶合效應之結構動態反應。研究結果顯示，基礎埋入深度影響結構受震反應甚大，當基礎埋入深度達基礎寬度一半以上，未考慮偶合效應將低估結構反應15%左右。
本文亦探討考慮偶合運動簡化模型之模擬精度，透過三維度整體分析模型驗證，結果顯示結構反應譜自然頻率約於12Hz以下時，簡化模型可精準評估結構反應；結構反應譜自然頻率超過12Hz以上時，簡化模型尚存在差異，但由於建築結構自然頻率多小於10Hz，故所建立之簡化模型適用於大多數建築結構分析。

As the high-tech industry is quite important for economic development, the seismic design standards of high-tech industrial buildings are more stringent than those of the general buildings. Since there are many precision instruments in high-tech industrial building which may be damaged for any small vibration, this study expect to simulate the actual response of the structure undergoing earthquakes for reliable seismic design.
In this study, five-story buildings undergoing horizontal earthquake are used to study the dynamic responses of the structure considering the coupling of horizontal and rocking motions. The results show that embedded depth of foundation affect seriously the responses of the structure undergoing earthquakes. As the embedded depth of foundation exceed the half length of the foundation, it would underestimate the response of the structure by 15%, if the coupling effect is not considered.
In this study, we also investigate the accuracy of the simplified model considering the coupling effect through three-dimensional analytical model. The result show that the simplified model can accurately estimate the response of the structure when the nature frequency of the structure response spectrum is below 12 Hz. When the nature frequency of the structure response spectrum exceed 12 Hz, the response of the simplified model exist deviations. Since the nature frequencies of most building structures are less than 10 Hz, the simplified model is considered suitable in most building structural analysis.

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