本研究開發出一適用於拉曼光學檢測的紙基微流體晶片，利用簡易微影製程製作的紙基微流體平台並塗佈一種新穎的具有表面拉曼增強光譜(SERS)特性的負載銀奈米粒子的中孔洞沸石材料(Ag@MZN)，使在拉曼訊號微弱的紙基平台上得以檢測檢體的拉曼光譜，並可成功應用於檢測常見的濫用藥物，本晶片開發成功後，將有助於提供一種易於使用且可靠的濫用藥物檢測系統。
本晶片利用易於取得且成本低廉的纖維素濾紙，配合使用簡易的微影製程設備、材料、方法及場地，製作出具有親水及疏水區域的紙基平台，再使用Ag@MZN材料於平台中之親水區域，可以低成本在任何實驗室製成。

In this study, a paper-based device was fabricated by low cost lithography process with Ag@MZN, a newly chemical compound used to detect the abuse or misuse of drugs with Surface-Enhanced Raman Spectroscopy(SERS). Three experiments were conducted, including: (1) studying different parameters to optimize the lithography fabrication process; (2) studying the coverage efficiency of Ag@MZN on the surface of paper-based channels with different coating methods; (3) quantifying the SERS signal of Ketoprofen on the paper-based devices which were fabricated by different parameters or fabrication processes.
The experiment results showed that the paper-based devices could be successfully fabricated by low cost and coated with Ag@MZN, and the SERS signal of Ketoprofen could be detected.

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