琥珀酸是目前工業用途上相當具有前景的一項商品，於民生的應用亦非常廣泛。目前有許多研究提出不同的琥珀酸回收方法，像是沉澱、萃取、離子交換及蒸餾等，但無法完全處理廢液與能源消耗的成本問題(回收琥珀酸占整個製程成本的50%~80%)，成了製程的一個難題，故未能有完整的工業程序應用於工廠製程。本研究係探討回收琥珀酸的製程，由琥珀酸醱酵液與乙醇反應後生成琥珀酸二乙酯，再應用乙二醇分離乙醇與水，將此流程進行程序設計與控制。首先尋找適合的熱力學及動力學參數，應用Aspen Plus v8.4進行穩態模擬，再進行程序設計，以最小化年度總成本(TAC)為目標，提出系統之最適化設計，分別討論反應蒸餾塔及分離蒸餾塔兩系統之設計概念與最適化結果，進而提出整廠的流程設計，並將乙醇與乙二醇之反應物回收利用。最後，探討整廠製程之控制策略，利用Aspen Dynamic進行動態模擬及控制。控制策略方面，使用基本的控制環路包括液位、溫度、流量、壓力控制器，並且利用敏感度分析找出每一個操作單元最適合的溫度控制點，分別給予每個蒸餾塔之塔頂及塔底的控制，接著設定進料量增減及進料組成改變進行干擾，找到一個控制策略能使整個系統在干擾下快速回穩，並能保持產物的純度。

In this research, we are probe about recovery of succinic acid from fermentation broths with process design and control. Succinic acid is extensively applies in industry and our daily lives, which is one of the most promising commodities in the chemical industry. However, the problem of manufacturing succinic acid does always exist. The recovery of succinic acid process takes up about 50% to 80% of processing cost. Many have attempted to improve and reduce separation steps, but up to now there is not a successful technology scaled up to industrial production. Despite the fact that several separation processes have been proposed to overcome this problem (precipitation, ion exchange resins, membranes, reactive extraction, and liquid-liquid extraction), none addresses the major limit of large energy and material requirements as well as waste generation.
First of all, suitable thermodynamic and kinetic model are chosen to describe this process and perform the steady-state simulation by Aspen Plus. The system in this process is a reversible reaction and seeking out the optimum goal is obtained by minimizing the Total Annual Cost (TAC). After two optimum designs which are about reactive distillation column and separate distillation column are obtained, we connect each unit into a plant-wide process and recycle the un-reacted reactants. Then, we change the feed location to look for the optimum process.
After that, we will discuss the dynamic simulation and control of the plant-wide process by Aspen Dynamic. A simple control strategy including level, temperature, pressure and flow control has been brought forward, and the sensitivity analysis is performed to find the suitable control of each unit. With the interference by adjusting the feed flow rate and feed composition, the proposed control strategy works effectively and holds the purity of the product.

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