近二十年來，表面電漿共振生物感知器(Surface plasmon resonance biosensor, SPR biosensor)，一種利用光學技術設計的生物感測器，其利用特定分子與待測分子在介面專一性的交互作用，而產生介面特性改變的方式，來分析生物分子間的交互作用。
在本論文之中會一一介紹自行設計之表面電漿共振生物感知器，從其優點至缺點作基本的介紹。並會討論與其相關的解決辦法或是補償之處。
文中最主要的相關解決辦法是使用能降低光源發散角的微透鏡陣列(Micro lens array, MLA)來改善其光路的準直度及降低雜散光的發生，並對於MLA使用實測後的結論作各種面向的探討，其中包含了對MLA的建模及模擬方法、使用上遇到的困難。最後則是由上述綜合所得出的結論，作一系列的修正及改進。
對系統作一個最後的總整理後，將從系統的光路校正、設計方向、微流道改良等等，給出未來所需要加強的地方。

In the past two decades, Surface plasmon resonance, SPR biosensor, a biosensor designed using optical technology, utilizes the interaction of specific molecules with the molecules to be tested in the interface. The way in which changes in interface properties are produced to analyze interactions between biomolecules.
In this paper, we will introduce the surface-plasma resonance biosensor designed by ourselves, from the advantages to the lack of basic introduction. It will discuss the solutions or compensation related to it.
The most important solution in this paper is to use a Micro Lens Array, MLA that reduces the divergence angle of the light source to improve the collimation of the optical path and reduce the occurrence of stray light, and to make various conclusions for the MLA using the measured results. The oriented discussion includes the modeling and simulation methods of MLA and the difficulties encountered in its use. Finally, the conclusions from the above synthesis are a series of corrections and improvements.
After a final finalization of the system, the optical path correction, design direction, microchannel improvement, etc. of the system will be given to the future needs to be strengthened.

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