生物活性玻璃因其優異的生物活性及可降解性，已被廣泛地使用於各種臨床應用，如骨替代材料、牙科填料、藥物載體和軟組織填充劑等。而含有SiO2-CaO-P2O5組成的含硼生物活性玻璃，能使材料與骨組織形成良好的鍵結，並刺激骨細胞分化與增殖，進而促進新生骨的形成。此外，藉不同摻雜以增加其性質，例如：摻雜銀可以提供抗菌的能力，摻雜鋅可以有抗發炎的效果，摻雜硼可以促進血管的形成等。相較於熔膠凝膠法有較短的製備時間、步驟簡單、且產量較大。因此本實驗擬利用噴霧乾燥法製備含硼生物活性玻璃，。藉由摻雜1mol%, 3 mol%, 5 mol%之含硼生物活性玻璃，並以熱重分析儀判斷其鍛燒溫度，以傅立葉轉換紅外線光譜儀、X光繞射儀、掃描式電子顯微鏡、光學顯微鏡、細胞存活率來分析其化學鍵結、結晶結構、表面形貌等性質、牛主動脈細胞增生狀況及細胞存活率。最後，結果顯示以噴霧乾燥法所製備之含硼生物活性玻璃可維持同樣具有生物活性，並且具有幫助牛主動脈細胞增生的作用，往後以傷口癒合及斷肢接合做為後續的發展。

The biological activity and degradability of bioluminescent glass has been widely used in various clinical applications, such as bone substitute materials, dental filler, drug carriers and soft tissue fillers. Among bioluminescent glasses, bioluminescent glass that contains SiO2-CaO-P2O5 can form good bonding between the materials and bones, stimulate bone cells to proliferate and differentiate, and promote bone regeneration. In addition, doping other material in the glass can introduce more functionality, for example, silver doping with antibacterial ability, zinc doping with anti-inflammatory ability, boron doping with angiogenesis. In this experiment, the boron doped bioglass was prepared by the spray drying method, which has the advantage of facile preparation, shorter producing time, and higher output when compared with the tradition sol-gel method. The calcining temperatures of the boron-containing bioglasses were first analyzed by thermogravimetric analyzer. The chemical compositions of them were determined by Fourier transform infrared spectrometer. X-ray diffractometer was implemented to study their crystallography. The surface morphologies were confirmed by scanning electron microscope and optical microscope. The bioactivity of boron-containing bioglasses was studied by cell survival and proliferation of bovine aortic cells. Finally, the results suggested that the boron-containing bioactive glass prepared by the spray drying method can promote cell survival and proliferation. The bioglass has the potential in would healing and replantation of amputated and limb amputated, and bone regeneration in the future.

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