通過附著奈米碳點塗覆的氧化鐵奈米顆粒（CNH / Fe3O4 @ C）來修飾作為藥物載體的奈米顆粒，以進行多種治療並增強其性能。 CNH / Fe3O4 @ C已成功合成，如先前報告的用於熱療和化學療法的組合療法。顯示出良好磁體響應的氧化鐵奈米顆粒是高溫的原因。同時，由於其能夠產生單線態氧的碳點如前所述，是光動力療法（PDT）的原因。對於化療研究，CNH / Fe3O4 @ C增強了阿黴素（DOX）負荷，DOX釋放以及吉西他濱負荷和吉盤西林釋放。還測量了DOX釋放和吉西他濱釋放的溫度依賴性，並導致在較高溫度下較高的藥物釋放。對於PDT研究，檢查了CNH / Fe3O4 @C產生的單線態氧。此外，已經進行了藥物釋放和光照射的組合，並且在藥物釋放方面顯示出良好的結果。

Carbon nanohorns as the drug carrier were modified by attaching the carbon dots coated iron oxide nanoparticles (CNH/Fe3O4@C) in order to perform multiple therapies and to improve their performance. CNH/Fe3O4@C has been successfully synthesized as previously reported for combination therapy of hyperthermia and chemotherapy. Iron oxide nanoparticles that showed a good magnet response are responsible to hyperthermia. Meanwhile, the carbon dots due to its ability to produce singlet oxygen as previous report are responsible to photodynamic therapy (PDT). Towards chemotherapy study, CNH/Fe3O4@C enhanced the doxorubicin (DOX) loading, DOX release and also gemcitabine loading, gemcitabine release. The temperature dependency of DOX release and gemcitabine release was also measured and resulted higher drug release in higher temperature. Towards the PDT study, the singlet oxygen generated by CNH/Fe3O4@C was examined. Furthermore, the combination of drug release and light irradiation has been performed and showed a good outcome in drug release.

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