研究生: |
劉榮展 Jung-Chan Liou |
---|---|
論文名稱: |
磷灰石/矽礦石複合β-三鈣磷酸鹽生醫玻璃陶瓷骨替代材之開發 Development of apatite/wollastonite and β-TCP glass-ceramic-based bone implants |
指導教授: |
施劭儒
Shao-Ju Shih |
口試委員: |
王丞浩
Chen-Hao Wang 陳祥和 Hsiang-Ho Chen 鍾仁傑 Ren-Jei Chung |
學位類別: |
碩士 Master |
系所名稱: |
工程學院 - 材料科學與工程系 Department of Materials Science and Engineering |
論文出版年: | 2016 |
畢業學年度: | 104 |
語文別: | 中文 |
論文頁數: | 116 |
中文關鍵詞: | A/W 生醫玻璃陶瓷 、β-三鈣磷酸鹽 、生物活性 、降解 、噴霧熱解 |
外文關鍵詞: | A/W glass-ceramic, β-tricalcium phosphate, Bioactivity, Degradation, Spray pyrolysis |
相關次數: | 點閱:604 下載:5 |
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自從1982年日本Kokubo團隊等人發明A/W 生醫玻璃陶瓷 (A/W glass-ceramic)後,因為其具有高強度、高硬度等機械性質,且同時擁有良好的生物活性,於臨床上廣泛的被應用於人工脊椎骨、椎間盤以及股骨等方面的修補;然而該材料降解速率極為緩慢,不利於新生骨生成時提供足夠的生長空間。為了彌補A/W 生醫玻璃陶瓷低降解速率的缺點,本研究藉由結合可吸收性生醫陶瓷β-三鈣磷酸鹽與A/W生醫玻璃陶瓷以改善其不足。實驗中以噴霧熱解法製備A/W-CP 生醫玻璃陶瓷前驅粉體,將其製作成塊材後以不同熱處理(700-1100oC)溫度進行燒結,並將燒結後塊材浸泡於模擬人體體液進行體外生物活性測試,發現經由1100 oC熱處理後之A/W-CP生醫玻璃陶瓷具有最佳生物活性,且較商用塊材(Cerabone®A-W) 有較高的降解性。本實驗以X光繞射儀分析熱處理後塊材之相組成,並鑑定生物活性測試後塊材相比例之變化;以掃描式電子顯微鏡觀察磷灰石層於表面生成情形。
The apatite/wollastonite glass-ceramic (A/W GC) was first reported by Kokubo in 1982. It has been widely applied in clinical fields such as artificial vertebrae, disc and femur repairing, because the A/W GC has the advantages of superior bioactivity and excellent mechanical properties. However, for A/W GC there are still some disadvantages, for instance, the degradation rate (almost no degradation) is too slow to provide the space for the new bone generation. In order to overcome the drawbacks of slow degradation rate, this study combined the A/W GC with resorbable bioceramics namely β-tricalcium phosphate (β-TCP) to increase the degradation rate. The apatite/wollastonite/β-TCP glass-ceramic powders were prepared by spray pyrolysis method, and as-prepared bulk samples were sintered under the various sintering temperatures of 700-1100oC. The phase compositions,and morphologies were characterized using X-ray diffraction and scanning electron microscopy, respectively. Also, the degradation rates of A/W-CP GC were measured. In conclusion, 1100 oC sintered A/W-CP GC sample has the highest bioactivity among samples. Moreover, A/W-CP GC samples have higher degradation rate than commercial product (Cerabone®AW).
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