經由統計發現，台灣隨著都市化、工業化以及氣候變遷等因素，使得罹患肺部支氣管疾病的人數大幅提升，其中又以氣喘最為盛行。目前治療氣喘的方式以吸入性藥物傳輸為主，因此藥物在被患者使用的同時，是否能確實並有效地傳送至肺部深處且被患部所吸收是相當重要的。透過一些文獻可知，先前許多研究都是利用電腦模擬軟體來進行肺部的給藥分析，而近幾年則是分別對大支氣管及肺部末端之肺泡模型，但始終仍缺乏一個完整的肺部支氣管模型進行給藥的模擬分析。
為了了解吸入性藥物是否能確實的傳送至肺部深處且被有效的吸收，本研究利用是來自日本山口大學的Fei Jiang教授所提供的肺部支氣管電腦斷層掃描檔案，使用非傳統加工製程來製作一全尺寸三維且透明肺部支氣管模型。製程步驟包括內外模具的設計、利用熔融擠製型3D列印機製作出內外模具、蒸氣表面拋光及後處理、彈性材料之澆鑄及兩階段的內模溶解技術，以製作出完整的肺部支氣管模型。
此一全尺寸且透明肺部支氣管模型完成後，本研究將建立一呼吸模擬器以模擬真實人體在使用噴霧治療器的情況下肺部的給藥情形，利用所製作出的口喉模型搭配噴霧治療器以及碘顯影劑將藥物傳送到肺部支氣管模型當中，並使用流量計和三向閥以模擬人體真實的流量，最後連接真空汞以模擬恆定的呼吸。接著使用電腦斷層掃描儀 (Computed Tomography)對給藥後的肺部支氣管模型進行掃描，並搭配醫學用軟體Materialise Mimics進行藥物於肺部支氣管內之沉積分析。

Statistics found in the past 30 years, in Taiwan, the number of people suffer from lung bronchial diseases has greatly increased. Among them, asthma is the most prevalent. For patients with asthma, most of the current medical treatments use inhaled drug delivery for treatment. Therefore, it is very important that the drug can be delivered to the deep lungs and effectively absorbed when it is used by patients. It can be seen from some literatures that many previous studies have used computer simulation software to analyze the drug delivery of the lungs. In recent years, simulation analysis of drug administration has been performed on the bronchi and the alveolar model of the lung terminal, but there has never been a complete model to complete the simulation.
In order to understand whether inhaled drugs can be delivered to the deep lungs and be effectively absorbed. In this study, a lung bronchi model provided by Professor Fei Jiang from Yamaguchi University in Japan was used to create a three-dimensional elastic lung bronchus model using a non-traditional process. In the process, through the design of internal and external molds, the use of melt extrusion 3D printing mechanism to make internal and external molds, steam surface polishing, elastic material casting and demoulding technology, and finally made a three-dimensional elastic lung bronchi model.
Then, using the created three-dimensional elastic lung bronchial model, establish a breathing simulator to simulate the actual drug delivery of the lungs of the human body using a nebulizer. In order to understand the situation of drug deposition, this study used a computer tomography scanner to scan the lung bronchi model, and use medical software Materialise Mimics for deposition analysis to establish a quantitative mechanism of drug deposition.

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