受到近幾年來醫療、衛生及生活形態的影響，慢性病(如心臟疾病、中風、癌症及糖尿病)已取代急性傳染病成為已開發或開發中國家的主要疾病。慢性病除了損害個人健康外，也會對家庭經濟及國家醫療支出造成沉重負擔。因此慢性病的防治與治療成為世界各國所著重的課題。目前醫院具備多種慢性病偵測方式，但醫療成本還是逐年高漲，如果能夠落實每天居家定時檢測，或許才能發揮早期偵測的效用。目前國內外各大廠積
極投入與研發居家診斷儀器，但面臨(1)硬體操作不方便、量測不夠精確(2)軟體分析缺乏可有效應用於疾病分析之指標、(3)量測結果缺乏臨床驗證等瓶頸，都尚未有顯著的成果出現。
有鑑於此，本研究從循環供血角度切入思考，血流供應與各生理組織運作息息相關。因此從循環供血尋找疾病指標或許能達到慢性病早期偵測。結合本實驗室過去累積臨床疾病指標與建置軟、硬體基礎。本研究自行開發心電圖(ECG)、動脈血壓波形(BPW)、血管光容積(PPG)量測系統，與現有設備雷射督卜勒血流儀(LDF)，搭配軟體分析程式建構出非侵入式循環生理參數量測分析系統。
本量測系統可以得到血液從心臟端一直到微循環端的資訊，可更了解血液循環系統中，從上游到下游的關係，上游我們量測心電訊號觀察心臟端狀態，在中游我們量測動脈管壁的傳遞過程，下游則是量測微循環端供血狀態，並運用非侵入式量測技術快速評估動脈管與局部血流的循環狀態，再以6項實驗來驗證本量測系統硬體穩定度與程式分析可靠度。
本量測系統在硬體部分已達到可自製、成本低、體積小、操作便利、接線簡單、量測精確又安全等優勢，藉由相關軟體分析實驗驗證本量測系統穩定可靠，具有良好的解析能力。能夠解決前述遠距醫療發展成本太高、實用性不高、不具生理意義等問題，期望未來能落實遠距醫療與居家照護。在預防醫學上，藉由數據變化之趨勢能與多種慢性疾病相互連結，真正落實早期發現與治療，提升臨床應用價值，本量測系統將協助世人共同對抗慢性病的威脅。

In recent years, with the influences of medical, health and lifestyles, chronic diseases like heart disease, stroke, cancer and diabetes has replaced acute infectious disease as the main diseases in developed or developing countries. Chronic diseases not only can damage one’s health but also cause a heavy burden for the family economy and medical expenses of nations. Therefore, how to prevent and treat chronic diseases has become an important issue for all counties around the world. Currently, hospitals have a variety of ways to detect chronic disease, but the medical costs are still getting higher year by year or if it can be implemented at home every day which may result in an early detection. At present, manufacturers actively devote to the research and development of home diagnostic instruments, but there are no significant breakthroughs due to following bottlenecks: (1) hardware is not convenient to operate and measurement is not precise enough;(2) software analysis is lack of effective criterion for applying to analysis of disease; (3) measurement results are lack of clinical proven.

In view of this, this study took the perspective on the circulation of blood that blood supply and the operation of the physiological organization are interacting. Therefore, we try to find disease indicators from the blood supply and probably obtain the early detection of chronic diseases. Combining with long accumulative clinical disease index and building software and hardware bases in our laboratory, the study adopted self-developed Electrocardiogram (ECG), Blood Pressure Waveform (BPW), Photo plethysmography (PPG) measuring system and the existing Laser Doppler Flowmeter (LDF) with software analysis program to construct non-intrusive measuring and analysis system of circulation physiological parameters.

The measuring system can obtain information of blood which is from the heart to the microcirculation side, a better understanding of the relationship in blood circulation system from upstream to downstream. Upstream we measured signals of the heart telecommunication to observe the state in cardiac side; in midstream we measured the transfer process of arterial wall; downstream blood supply status of microcirculation was measured. In addition, we used non-intrusive measuring technique to rapidly assess circulatory state of arteries and local blood flow and six experiments to verify the hardware stability and program reliability analysis of the measuring system.

This measuring system’s hardware has advantages of self-production, low cost, small size, convenient operation, simple wiring, precise measurement and safe. By relevant experiment of software analysis has verified the measuring system is stable and reliable with good analytical capability, which can solve the above-mentioned problems of telemedicine, such as high cost, not practicable and physiological significance. We hope implementations of telemedicine and home care can be achieved in the future. In preventive medicine, utilizing the connection between the trend of data change and a variety of chronic diseases to realize implementations of early detection and treatment, to improve the values of clinical application as well as the measuring system will together help people to cope with chronic diseases.

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