含高乙交酯含量的聚乳酸甘醇酸的開環聚合合成和結構表徵及其熱性能、形態和親水性

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研究生：	Phan Van Hoang Khang Phan Van Hoang Khang
論文名稱：	含高乙交酯含量的聚乳酸甘醇酸的開環聚合合成和結構表徵及其熱性能、形態和親水性 Synthesis and Structural Characterisations of Poly(L-lactide-co-glycolide) Containing High Glycolide Contents by Ring-Opening Polymerisation, and their Thermal Properties, Morphologies and Hydrophilicity
指導教授：	游進陽 Chin-Yang Yu
口試委員:	游進陽 Chin-Yang Yu 王丞浩 Chen-Hao Wang 施劭儒 Shao-Ju Shih
學位類別：	碩士 Master
系所名稱：	工程學院 - 材料科學與工程系 Department of Materials Science and Engineering
論文出版年：	2022
畢業學年度：	111
語文別：	英文
論文頁數：	84
外文關鍵詞：	Block copoymers, Ring-opening polymerisation, Composition ratio, Well-organised microstructure, Degree of crystallinity, Spherical particles
相關次數：	點閱：135 下載：4
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Ring-opening polymerisation has been utilised to synthesise the samples. For
block copolymers, poly(L-lactide) has been used as a macroinitiator for
polymerisation of glycolide in the presence of stannous octoate. For random
copolymers, it has been synthesised by copolymerisation of L-lactide and glycolide
using stannous octoate and 1-dodecanol as catalyst and initiator, respectively. The
percentage between glycolide and L-lactide is 90 and 10%, respectively. For block
copolymers, very few hetero-sequences are detected compared to that of random
copolymers. Block copolymers have smaller intrinsic viscosity compared to that of
random copolymers. Due to ill-organised microstructures, thermal stability of random
copolymers is relatively lower than that of the block copolymers. In addition, the
enthalpy of fusion and degree of crystallinity of random copolymers are also
relatively lower than those of the block copolymers. Block copolymers tend to
aggregate with micro-phase separation due to unique self-assembly behaviours. The
average diameter of block copolymers is about 200 nm, which is relatively smaller
than the average diameter of random copolymers (about 1000 nm). Finally, the
hydrophilicity of random copolymers is relatively higher than the hydrophilicity of
block copolymers.

Abstract ........................................i
Chapter 1 Introduction and Aims............................................1
Introduction ............................................................2
1.1.1 Biodegradable polymer..............................................2
1.1.2 Copolymer .........................................................5
1.1.2.1 Random copolymer................................................................6
1.1.2.2 Alternating copolymer .........................................6
1.1.2.3 Graft copolymer..................................................6
1.1.2.4 Block copolymer.................................................7
1.1.3 Poly(lactide-co-glycolide) ........................................8
1.1.3.1 Development and commercialisation of poly(lactide-coglycolide) ........................................................................8
1.1.3.2 Precursors for synthesis of poly(lactide-co-glycolide) .........10
a. Lactide.........................................................10
b. Glycolide.....................................................11
1.1.3.3 Synthesis of poly(lactide-co-glycolide)................................13
a. Direct polycondensation .............................................13
b. Ring-opening polymerisation ..............................................14
1.1.3.4 Block copolymers of polylactide and polyglycolide ............19
1.1.3.5 Properties of poly(lactide-co-glycolide) ...............................21
a. Influences of composition ratio on properties of poly(lactide-coglycolide) .............................................................................21
b. Influences of microstructure on properties of poly(lactide-coglycolide) .........................................................................25
1.1.3.6 Applications of poly(lactide-co-glycolide)...........................28
a. Agricultural and aquaculture applications ................................28
b. Antimicrobial packaging....................................................29
c. Biomedical applications...............................................31
Aims of study ..............................................................33
Chapter 2 Results and Discussion .........................................34
Ring opening polymerisation of homopolymer PLA, block
copolymers P1b-P3b and random copolymers P1r-P3r......................35
Composition ratio analysis of block copolymers P1b-P3b and
random copolymers P1r-P3r ................................................37
Chain microstructure analysis of block copolymers P1b-P3b and
random copolymers P1r-P3r ................................................41
End-group analysis of block copolymers P1b-P3b and random
copolymers P1r-P3r ......................................................45
Functional groups of homopolymer PLA, block copolymers P1bP3b, and random copolymers P1r-P3r.............................48
Intrinsic viscosity and viscosity average molecular weight of
homopolymer PLA, block copolymers P1b-P3b and random copolymers P1r-P3r
.....................................49
Thermal properties of homopolymer PLA, block copolymers P1bP3b and random copolymers P1r-P3r..................................................................51
Morphologies of homopolymer PLA, block copolymers P1b-P3b
and random copolymers P1r-P3r ...........................................56
Hydrophilicity of homopolymer PLA, block copolymers P1b-P3b
and random copolymers P1r-P3r ...........................................59
Chapter 3 Conclusion .................................................................62
Chapter 4 Experimental Section..............................................63
Materials, instrumentation and characterisation..............................64
Synthesis of polymers ............................................65
4.2.1 Synthesis of homopolymer, poly(L-lactide) (PLA).....................65
4.2.2 Synthesis of block copolymer, poly(L-lactide-b-glycolide) (P1b)..
........................................................................66
4.2.3 Synthesis of block copolymer, poly(L-lactide-b-glycolide) (P2b)..
.........................................................................67
4.2.4 Synthesis of block copolymer, poly(L-lactide-b-glycolide) (P3b).......................................................... 68
4.2.5 Synthesis of random copolymer, poly(L-lactide-r-glycolide) (P1r)
................................................................ 69
4.2.6 Synthesis of random copolymer, poly(L-lactide-r-glycolide) (P2r)
............................................................... 70
4.2.7 Synthesis of random copolymer, poly(L-lactide-r-glycolide) (P3r)
............................................................... 71
References .................................................... 72
Appendix ...................................................... A1
                                

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