丁二烯是重要的有機化工原料，是合成橡膠的重要單體，亦可用來合成樹酯及許多化工產品。丁二烯的主要來源為輕油裂解後的碳四混合物，藉由萃取蒸餾提純取得。石油危機的爆發，進而影響到丁二烯的產能。另一種利用乙醇做為原料製備丁二烯的程序在二戰過後由於較不符合經濟效益而不被廣泛應用。然而，隨著頁岩氣(shale gas)開採技術的提升，以頁岩氣為進料生產乙烯的成本約比石油腦為進料成本低50 %，而乙烯可作為合成乙醇的原料，藉此提升乙醇法生成丁二烯製成的價值。
本研究利用Aspen Plus進行乙醇脫氫合成丁二烯的製程設計與模擬，乙醇先藉由脫氫反應生成中間產物乙醛，而在第二個反應器中乙醛與乙醇反應生成產物丁二烯。熱力學模型選用NRTL-HOC以及Henry component。設定的產能為200,000噸95 wt%的丁二烯產品。共完成四種不同的設計架構。
第四種設計架構為改善前三種架構中所發現的缺點，在經濟評估的結果亦能得到最小的年總成本(total annual cost, TAC)，為本研究中最符合經濟效益的設計架構。

1,3-butadiene is a chemical compound that is frequently used as a monomer in the production of synthetic rubber. The most common technique for production of butadiene is extraction from the unsaturated hydrocarbon mixture produced from steam cracking. As the oil crisis appear, some other manufacture method need to be improved to replace the existing process. A method using ethanol as material to synthesize butadiene was used in United State during the World War II, since then it has not been widely research since it is less economical due to the high ethanol price. However, with the improvement of the drilling technology for the shale gas, using shale gas to synthesize ethanol can largely decrease the ethanol price, and hence make the ethanol-to-butadiene process more profitable.
This research focused on the design and simulation of such butadiene process using Aspen Plus. NRTL-HOC was chosen for thermodynamic model. The product capacity is set to be 200,000 ton/year (200 KTA), 95 wt %.
Four design structures had been built, and the fourth design structure would have the lowest TAC.

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