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研究生: 曾子容
Tzu-Jung Tseng
論文名稱: 非接觸式射頻血壓感測器研發
Development of Noncontact Blood Pressure Sensors Using Radio-Frequency Technology
指導教授: 曾昭雄
Chao-Hsiung Tseng
口試委員: 瞿大雄
Tah-Hsiung Chu
洪子聖
Tzyy-Sheng Horng
陳筱青
Hsiao-Chin Chen
學位類別: 碩士
Master
系所名稱: 電資學院 - 電子工程系
Department of Electronic and Computer Engineering
論文出版年: 2019
畢業學年度: 108
語文別: 中文
論文頁數: 68
中文關鍵詞: 非接觸式血壓量測手腕脈波訊號反射脈波傳播時間
外文關鍵詞: noncontact, blood pressure measurement, pulse wave signal, reflected pulse transit time
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  • 本論文之目的在於研究非接觸式之血壓量測方法,解決市面上血壓計在量測過程中會帶給量測者壓疼的不適感,並改善無法長時間監測血壓之狀況。因此本論文將利用兩種不同之感測器量測手腕脈波訊號,該兩種感測器分別為本實驗室所設計之微擾注入鎖定原理感測器,以及使用24 GHz 之雷達感測器。兩感測器所量測之手腕脈波訊號分別經過數位訊號處理濾波後,擷取其中之反射脈波傳播時間,搭配本論文所推導出血壓計算公式進行校正並計算出血壓,最後與市售的血壓計ORMON HEM-7310比較及分析。本論文針對此兩種感測器分別進行單人及多人的量測並計算出血壓,在為本實驗室所設計之微擾注入鎖定原理感測器的量測結果中,其中單人量測血壓的SBP與DBP之誤差分別,2.565.61 mmHg與3.513.34 mmHg,而綜合多人量測,其平均誤差率則分別為SBP -2.3811.14 mmHg與DBP 0.936.15 mmHg。使用24 GHz之雷達感測器的單人量測結果SBP與DBP的最大誤差分別為0.555.44 mmHg與 2.263.93 mmHg。
    本論文所提出之血壓量測方法,具有非接觸之優點,適用於長期監測所用,且與市面上販售之血壓計的數據有吻合的量測結果。


    The aim of this thesis is to develop a noncontact cuffless blood pressure measurement, that offers a new feature for healthcare applications to reduce the discomfort when measuring with sphygmomanometer. In this thesis, blood pressure (BP) calculations using reflected pulse transit time (R-PTT) measured with two types of sensors: perturbation-injection-locked (PIL) sensor, and the 24 GHz radar sensor. In the experiments, ORMON HEM-7310 is taken as reference. For single subject using the PIL sensor, the difference of systolic blood pressure (SBP) is 2.565.61 mmHg and that of the diastolic blood pressure (DBP) is 3.513.34 mmHg. Using the same sensor for multiple subjects, the average differences of SBP and DBP are -2.3811.14 mmHg and 0.936.15 mmHg, respectively. For single subject using the 24 GHz radar sensor, the difference of SBP is 0.555.44 mmHg and that of DBP is 2.263.93 mmHg. Overall, our findings demonstrate the potential of a noncontact blood pressure measurement system, and reveals that the results match with the blood-pressure monitor. This noncontact approach will likely impact the future design of cuffless BP measurement.

    致謝 I 摘要 II Abstract III 目錄 IV 圖目錄 VI 第一章 序論 1 1.1 前言 1 1.2 研究動機與目的 5 1.3 文獻探討 6 1.4 章節說明 7 第二章 血壓計算演算法 8 2.1 PTT與血壓 8 2.1.1 血壓計算演算法一 8 2.1.2 血壓計算演算法二 10 2.1.3 實作結果 10 2.2 R-PTT與PTT 18 2.3 訊號擷取與處理 19 2.3.1 訊號濾波 20 2.3.2 計算R-PTT 23 2.3.3 血壓計算方程式 24 第三章 5.8 GHz微擾注入鎖定感測器應用於血壓量測 25 3.1 系統架構 25 3.2 模組設計 27 3.2.1 CSRR設計與量測 28 3.2.2 射頻放大器 29 3.2.3 解調電路 30 3.2.4 基頻電路 30 3.3 R-PTT與PTT實驗流程與結果 31 3.3.1 實驗流程 31 3.3.2 實驗結果 32 3.4 R-PTT與血壓實驗流程與結果 34 3.4.1 實驗流程 34 3.4.2 實驗結果 35 第四章 24 GHz雷達感測器應用於血壓量測 38 4.1 系統架構 38 4.2 模組設計與測量 39 4.2.1 微帶天線量測 40 4.2.2 雷達天線晶片 40 4.2.3 PLL電路晶片 41 4.3 R-PTT與血壓實驗流程與結果 45 4.3.1 實驗流程 45 4.3.2 實驗結果 46 第五章 結論與討論 50 參考文獻 52

    [1] ASUS VivoWatch BP (HC-A04) [online]. Available: https://www.asus.com/ VivoWatch/ASUS-VivoWatch-BP-HC-A04
    [2] Cuffless blood pressure, oxygenation, heart rate monitor receives 510(k) clearance[online].Available:https://www.mobihealthnews.com/news/north-america/ cuffless-blood-pressure-oxygenation-heart-rate-monitor-receives-510k-clearance
    [3] Health Promotion Administration, Ministry of Health and Warfare, Healthy Diet. Healthy Blood Pressure, 2016, ROC. [online]. Available: https://www.mohw.gov.tw/cp-3795-41794-1.html
    [4] Health Promotion Administration, Ministry of Health and Warfare, 2016, [online]. Available: https://www.mohw.gov.tw/cp-3795-41794-1.html
    [5] World Health Federation, Elevating Hypertension on the Public Health Agenda, 2018, Available: https://www.world-heart-federation.org/news/elevating-hypertension-public-health-agenda/
    [6] Health Promotion Administration, Ministry of Health and Warfare, [online]. Available: https://dep.mohw.gov.tw/DOS/cp-1720-7324-113.html
    [7] Health Promotion Administration, Ministry of Health and Warfare, news, 2018 [online]. Available: https://www.hpa.gov.tw/Pages/Detail.aspx?nodeid=1405&pid=8667
    [8] American Heart Association, Understanding Blood Pressure Readings, [online]. Available:https://www.heart.org/en/health-topics/high-blood-pressure/understanding-blood-pressure-readings
    [9] Spiritmedical, Mercurial Desk Model Sphygmomanometer CK-101, [online]. Available: http://www.spiritmedical.com.tw/portfolio-items/ck-101-mercurial-desk-model-sphygmomanometer/
    [10] Spiritmedical, Wall Model Large Round Face Aneroid Sphygmomanometer1u1 CK-131, [online]. Available: http://www.spiritmedical.com.tw/portfolio-items/ck-131-wall-model-large-round-face-aneroid-sphygmomanometer/?portfolioCats=67%2C68%2C66
    [11] OMRON, Omron digital upper arm type blood pressure monitor HEM-7310, [online]. Available:https://www.omronhealthcare.com.tw/product/ins.php?index_prm_id=0&index_id=5
    [12] Infiniti, ProComp5 Infiniti System with BioGraph Infiniti Software-T7525, [online]. Available:http://thoughttechnology.com/index.php/hardware/procomp5-infiniti-5-channel-biofeedback-neurofeedback-system-w-biograph-infiniti-software.html
    [13] PHILIPS, Bedside patient monitor, [online]. Available: https://www.usa.philips.com /healthcare/product/HC865241/intellivue-mx700-patient-monitor
    [14] T. Tu and P.C.-. Chao, "Optimal Design of a New Strain-Type Sensor for Cuff-Less Blood Pressure Measurement via Finite Element Modeling and Taguchi Method," IEEE Sensors Journal, vol. 19, no. 22, pp. 10355-10364, 15 Nov.15, 2019.
    [15] M.-C. Tang, C.-M. Liao, F.-K. Wang and T.-S. Horng, "Noncontact Pulse Transit Time Measurement Using a Single-Frequency Continuous-Wave Radar," 2018 IEEE/MTT-S International Microwave Symposium - IMS, Philadelphia, PA, 2018, pp. 1409-1412.
    [16] H. Zhao, X. Gu, H. Hong, Y. Li, X. Zhu and C. Li, "Non-contact Beat-to-beat Blood Pressure Measurement Using Continuous Wave Doppler Radar," 2018 IEEE/MTT-S International Microwave Symposium - IMS, Philadelphia, PA, 2018, pp. 1413-1415.
    [17] P.-K. Chan, C.-C. Chen, and C.-L. Yang, "Systolic and Diastolic Blood Pressure Estimation from Pulse Transit Time Using Dual Split-Ring Resonators with Notch Structure," 2019 IEEE MTT-S International Microwave Symposium-IMS 2019 (pp. 361-364).
    [18] Y. Choi, Q. Zhang, and S. Ko, "Noninvasive cuffless blood pressure estimation using pulse transit time and Hilbert–Huang transform," 2013 Computers & Electrical Engineering, Vol. 39. Issue 1. pp.103–111. January 2013.
    [19] Y. Zheng, B. P. Yan, Y. Zhang and C. C. Y. Poon, "An Armband Wearable Device for Overnight and Cuff-Less Blood Pressure Measurement," IEEE Transactions on Biomedical Engineering, vol. 61, no. 7, pp. 2179-2186, July 2014.
    [20] S.C. Millasseau, S.J. Patel, S. Redwood, J.M. Ritter, and P.J.Chowienczyk, "Pressure wave reflection assessed from the peripheral pulse: is a transfer function necessary? " Hypertension, vol. 41, pp. 1016-20, 2003.
    [21] A.P. Avolio, L.M. Van Bortel, P. Boutouyrie, J.R. Cockcroft, C.M. McEniery, A.D. Protogerou, M.J. Roman, M.E. Safar, P. Segers, H. Smulyan, "Role of Pulse Pressure Amplification in Arterial Hypertension Experts' Opinion and Review of the Data". Hypertension. vol. 54. 375-83.
    [22] Y.-Y. Zhang, Z.-C Ma, Y.-N. Sun, "Radial pulse transit time is an index of arterial stiffness, " Hypertension Research, vol. 34, pp. 884–887, 2011.
    [23] 吳承洲,基於自振式互補間隙環形共振器之微擾注入鎖定生理訊號感測器研製,國立台灣科技大學電子工程學系碩士論文,民國108年。
    [24] MEDIATEK, MT7697 [Online] Available:https://www.mediatek.com/products/smart Home/mt7697.
    [25] C.-H. Tseng and C.-Z. Wu, “A Novel Microwave Phased- and Perturbation-Injection-Locked Sensor with Self-Oscillating Complementary Split–Ring Resonator for Finger and Wrist Pulse Detection,” submitted to IEE Transactions, in revision.
    [26] R. Adler, “A study of locking phenomena in oscillators,” Proc. IEEE, vol. 61, pp. 1380–1385, Oct. 1973.
    [27] K. Kurokawa, “Injection locking of microwave solid-state oscillators,” Proc. IEEE, vol. 61, pp. 1336–1410, Oct. 1973.
    [27] Infineon, BFP405F Low profile wideband silicon NPN RF bipolar transistor, [Online] Available: https://www.infineon.com/dgdl/Infineon-BFP405F-DS-v02_00-EN.pdf?fileId=5546d462689a790c01690f03259e390e.
    [28] Texas Instruments, OPA170 Low-Power Operational Amplifiers, [Online]Available: https://www.ti.com/lit/ds/symlink/opa170.pdf
    [29] Infineon, BGT24LTR11N16 24GHz Radar MMIC, [Online]Avilable:https://www.infineon.com/dgdl/Infineon-BGT24LTR11N16-DS-v01_03-EN.pdf?fileId=5546d4625696ed7601569d2ae3a9158a
    [30] Analog Devices, ADF4108 PLL Frequency Synthesizer, [Online] Available: https://www.analog.com/media/en/technical-documentation/data-sheets/ADF4108.pdf
    [31] CTS Corporation, Model 520 Temperature Compensated Crystal Oscillator, [Online] Available: https://www.ctscorp.com/wp-content/uploads/2015/11/008-0371-0.pdf
    [32] Texas Instruments, LM358 Low-Power Dual-Operational Amplifiers, [Online]Available: http://www.ti.com/lit/ds/symlink/lm2904-n.pdf

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