磷灰石矽灰石玻璃(AWGCs)陶瓷最早由Kukobo於1982年所創造，因其優異的機械性能及高生物相容性而被廣泛應用於醫學領域。這些材料由磷灰石及方解石組成，經熱處理後形成磷灰石、方解石和白鎖骨石的微細晶體。這種晶體之生成可增加材料機械強度且提升其生物活性。儘管這些材料應用廣泛，但尚未有利用噴霧熱解技術合成之A-W GCs生物活性和細胞毒性相關研究。因此，進行以確定這些材料之性能研究。
大量樣品將在700ºC至1100ºC之區間進行燒結並利用X光繞射和掃描式電子顯微鏡分析了樣品之相組成和形貌分析。此外，進行A-W GCs之降解速率檢測。
研究結果顯示，在所有AWGC樣品中以1100ºC燒結之樣品擁有最高生物活性。同時，此樣品之低毒性也表明在生物應用中具有高度相容性。
這些發現表明，AWGCs因擁有優異之生物相容性及機械性質，故利用噴霧熱解技術合成AW GCs可為生醫領域中一個可行替代方案。進一步研究並改進新型A-W GCs可帶來更強大潛力之醫學應用領域。

This study focuses on the synthesis, characterization, and in vitro testing of an apatite-wollastonite glass ceramic (AWGC) with specific percentages of apatites, wollastonite, and an amorphous phase. The AWGC was first introduced by Kokubo in 1982, combining the desirable properties of bioactive wollastonite and apatite with those of a resorbable P-Ca-rich glass. To enhance the material's bioactivity, heat treatment was conducted at different temperatures (ranging from 700ºC to 1100ºC), resulting in the precipitation of fine crystals of apatite, wollastonite, and whitlockite. This treatment increased the average surface density to 2.49±0.32 g/cm3. The bioactivity of the AWGC was assessed by immersing samples in a simulated bodily fluid (SBF) for varying time periods (3, 5, 7, 14, and 21 days) at 37°C. The results indicated a correlation between bioactivity, sintering temperature, and soaking time in SBF. The continuous disintegration of the amorphous and wollastonite phases occurred, releasing P and Ca ions into the SBF medium during soaking.
The phase compositions and morphologies were analyzed using X-ray diffraction and scanning electron microscopy, while degradation rates were calculated to determine average weight loss (%), found to be 2.59±1.6. Notably, the AWGC sample sintered at 1100ºC demonstrated the highest bioactivity after SBF immersion. One key advantage of the AWGC sample is its pH value produced during SBF immersion, falling within the range of (7.4-8.2) and remaining below 8.5. This indicates improved compatibility for biological applications with reduced toxicity, making it a promising material for biomedical uses.

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