本論文開發了一套低功率無線血壓計系統，此系統包含一自製之血壓計和一智慧型手機。血壓計使用單一低功耗藍牙系統單晶片(Bluetooth Low Energy System on Chip)完成血壓量測演算法並透過最新的低功耗藍牙技術將資料傳輸到智慧型手機。使用者可以從手機上得到收縮壓、舒張壓、平均壓和脈搏率等資訊。資料傳輸封包格式是依照Bluetooth SIG定義的Blood Pressure Profile規範去撰寫傳輸封包格式，因此具有高的相容性。
本論文自製的血壓計分為自動充氣和手動充氣兩種，手動充氣式血壓計的量測功率消耗非常低，在使用220mAh的電池下，量測次數可達到4,400次。本論文使用CuffLink模擬器驗證了自製血壓計的脈搏率和血壓值量測的準確度，脈搏率的準確度為-1.13±0.52下。收縮壓的準確度為0.69±1.63 mmHg，舒張壓的準確度為0.20±1.02 mmHg。此外，在臨床實驗的結果顯示本裝置收縮壓與聽診法的差異為2.66±2.71 mmHg，舒張壓與聽診法的差異為3.42±4.42 mmHg。都具有相當高的準確度。

In this thesis, we developed a low-power wireless blood pressure monitor system, which comprises a homemade blood pressure measuring device and a smartphone. The device uses single chip (Bluetooth Low Energy System on Chip, BLE SoC) to process the algorithm of blood pressure measurement and perform data transmission. Through the newest Bluetooth Low Energy interface, this device can send measured results to the smartphone. Therefore, users can see the systolic, diastolic, mean blood pressure and pulse rate information on the smartphone. Besides, the data transmission packet format is based on the standard Blood Pressure Profile specification. Therefore, it has high compatibility to communication with other devices.
The blood pressure measuring device can be divided into automatic and manual inflation mode in this thesis. It has very low power consumption and provides 4,400 measurements with a 220mAh battery in manual mode. For the reliability, the accuracy of pulse rate, systolic and diastolic blood pressures were verified by the CuffLink simulator. The accuracy of pulse rate is -1.13 ± 0.52 beats, the accuracy of systolic blood pressure is 0.69 ± 1.63 mmHg, and the accuracy of diastolic blood pressure is 0.20 ± 1.02 mmHg. In clinical trials, the systolic blood pressure average differences between our method and auscultation method is 2.66 ± 2.71 mmHg, the diastolic blood pressure average differences between our method and auscultation method is 3.42 ± 4.42 mmHg. As a result, this device has high accuracy for measuring blood pressure and pulse rate.

[1] 行政院衛生署國民健康局，「2007年台灣地區高血壓、高血糖、高血脂之追蹤調查研究」，臺灣(2007)。
[2] R. J. McManus, J. Mant, A. Roalfe, R. A. Oakes, S. Bryan, H. M. Pattison, and F. D. Hobbs, "Targets and self monitoring in hypertension: randomised controlled trial and cost effectiveness analysis," BMJ, vol. 331, p. 493, Sep 3 2005.
[3] 劉欣飴，「2011臺灣智慧型裝置持有與服務使用行為調查報告」，財團法人資策會創新應用服務研究，臺灣(2011)。
[4] Mobile Telephony Market. Available: http://www.bluetooth.com/Pages/Mobile-Telephony-Market.aspx
[5] PC & Peripherals Market. Available: http://www.bluetooth.com/Pages/PC-Peripherals-Market.aspx
[6] 陳泰全，「藍芽系統之省電方式研究與改善」，碩士論文，國立台北科技大學，臺北(2011)。
[7] W. J. Li, Y. L. Luo, Y. S. Chang, and Y. H. Lin, "A wireless blood pressure monitoring system for personal health management," in Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE, 2010, pp. 2196-2199.
[8] J. Jiehui, Y. Zhuangzhi, S. Jun, P. Kandachar, and A. Freudenthal, "A Mobile Monitoring System of Blood Pressure for Underserved in China by Information and Communication Technology Service," Information Technology in Biomedicine, IEEE Transactions on, vol. 14, pp. 748-757, 2010.
[9] P. Zhongbao, H. Chao, L. Jingsheng, and C. Tianhai, "Design of embedded remote monitoring terminal based on 3G network," in Complex Medical Engineering (CME), 2011 IEEE/ICME International Conference on, 2011, pp. 274-278.
[10] S. C. Yeh, W. Y. Hwang, T. C. Huang, and W. K. Liu, "U-healthcare System Deployment," in Bioinformatics and Bioengineering (BIBE), 2011 IEEE 11th International Conference on, 2011, pp. 137-142.
[11] T. Tamura, I. Mizukura, M. Sekine, and Y. Kimura, "Monitoring and Evaluation of Blood Pressure Changes With a Home Healthcare System," Information Technology in Biomedicine, IEEE Transactions on, vol. 15, pp. 602-607, 2011.
[12] C. Peng, N. Chaimanonart, W. H. Ko, and D. J. Young, "A Wireless and Batteryless 10-Bit Implantable Blood Pressure Sensing Microsystem With Adaptive RF Powering for Real-Time Laboratory Mice Monitoring," Solid-State Circuits, IEEE Journal of, vol. 44, pp. 3631-3644, 2009.
[13] D. J. Young, "Development of wireless batteryless implantable blood pressure-EKG-core body temperature sensing microsystem for genetically engineered mice real time monitoring," in Nano/Molecular Medicine and Engineering (NANOMED), 2009 IEEE International Conference on, 2009, pp. 259-264.
[14] A. Tahat, A. Sacca, and Y. Kheetan, "Design of an integrated mobile system to measure blood pressure," in Communications and Vehicular Technology in the Benelux (SCVT), 2011 18th IEEE Symposium on, 2011, pp. 1-6.
[15] J. G. Webster, Medical Instrumentation Application and Design, 4th ed.: John Wiley & Sons, 2009.
[16] Specification of the Bluetooth System, Version: 4.0, Jun 2010.
[17] 2.4-GHz Bluetooth™ low energy and Proprietary System-on-Chip. Available: http://www.ti.com/lit/ds/symlink/cc2541.pdf
[18] 1.8V, 2.9μA, 90kHz, Rail-to-Rail I/O OPERATIONAL AMPLIFIERS. Available: http://www.ti.com/lit/ds/symlink/opa4379.pdf
[19] MPS-3110 Series Pressure Sensor. Available: http://www.metrodyne.com.tw/datasheets/ch/MPS/MPS-3110series.pdf
[20] Texas Instruments CC2540/41 Bluetooth® Low Energy Software Developer's Guide v1.2.1 . Available: http://www.ti.com/lit/ug/swru271b/swru271b.pdf
[21] Blood Pressure Profile (Bluetooth Specification), Version: 1.0. Available: https://www.bluetooth.org/Technical/Specifications/adopted.htm
[22] "ISO/IEC/IEEE Health informatics--Personal health device communication--Part 20601: Application profile--Optimized exchange protocol," ISO/IEEE 11073-20601:2010(E), pp. 1-208, 2010.
[23] Blood Pressure Service (Bluetooth Specification), Version: 1.0 Available: https://www.bluetooth.org/Technical/Specifications/adopted.htm
[24] ANSI/AAMI SP10:2002, A1:2003: Manual, electronic, or automated sphygmomanometer , 2002.