研究生: |
羅濟生 Chi-sheng Lo |
---|---|
論文名稱: |
製備與評估具藥物釋放功能之牙科組織調理材 Preparation and In Vitro Evaluation of Drug Loaded Tissue Conditioners |
指導教授: |
高震宇
Chen-yu Kao |
口試委員: |
石淦生
Kan-sheng Shih 洪伯達 Po-da Hong |
學位類別: |
碩士 Master |
系所名稱: |
應用科技學院 - 醫學工程研究所 Graduate Institute of Biomedical Engineering |
論文出版年: | 2012 |
畢業學年度: | 100 |
語文別: | 中文 |
論文頁數: | 128 |
中文關鍵詞: | 組織調理材 、抗發炎藥物 、抗真菌藥物 、義齒性口腔炎 、白色念珠菌 |
外文關鍵詞: | tissue conditioner, anti-inflammatory drug, anti-fungal drug, denture-related stomatitis, candida albicans |
相關次數: | 點閱:310 下載:6 |
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本研究目的在發展一個具多功能之組織調理材(tissue conditioner, TC),使其具備快速釋放抗發炎藥物與長效性釋放抗真菌藥物之特點,以其為日益漸增的義齒性口腔炎患者提供一個新的治療策略,同時亦可減少患者往返醫院之頻率及龐大的醫療花費。其中抗發炎藥物Flurbiprofen (FB)可較迅速釋放以減緩因配戴義齒術後產生的發炎反應,而抗真菌藥物Itraconazole (ITZ)則以緩慢釋放方式達到長效性抑制口腔黏膜上的白色念珠菌之效果。初步結果顯示,此多功能組織調理材具有兩階段式藥物釋放之特性,在一周時間內從組織調理材中足以釋放96% 之FB,而ITZ則呈現長效緩慢釋放,釋放時間可持續兩周之久,此外,未來將結合in vitro細胞實驗及抑菌實驗的結果來尋求藥物間之最佳比例。
In this study, a drug incorporated tissue conditioner is developed for the delivery of Flurbiprofen (FB),an anti-inflammatory drug, and itraconazole (ITZ), an anti-fungal drug in the oral environment. This drug incorporated tissue conditioner provides two unique properties for treating denture-related stomatitis: (1) the tissue conditioner is used to reduce the damage of unfit denture by cushioning the hard denture base against the healing extraction sites. (2) the tissue conditioner is used as a depot for both anti-inflammatory drugs and anti-fungal drugs. In our study, the drug incorporated tissue conditioner showed a dual-phase release kinetics. The hydrophilic anti-inflammatory drug was rapidly released (96% of FB was released in a 7 day period) and the hydrophobic anti-fungal drug was released at a relatively slow pattern (30% of ITZ was released within 7 days, and 33% released within 14 days). We expected this drug incorporated tissue conditioner will create a synergistic effect of physical/chemical therapy for treating denture related stomatitis.
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