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研究生: 侯樂希
Jose Horacio Lizama De Marchena
論文名稱: 生物檢測載台之技術分析-以PCB與紙微流道為例
Insights on biosensing platforms in the case of PCB- and paper-based microfluidic devices
指導教授: 曾修暘
Hsiu-Yang Tseng
口試委員: 陳羽薰
Yu-Hsun Chen
侯欣翰
Hsin-Han Hou
學位類別: 碩士
Master
系所名稱: 工程學院 - 機械工程系
Department of Mechanical Engineering
論文出版年: 2023
畢業學年度: 111
語文別: 英文
論文頁數: 60
中文關鍵詞: Paper microfluidicsLab-on-PCBin-vitro diagnosticslean startupminimum value product
外文關鍵詞: Paper microfluidics, Lab-on-PCB, in-vitro diagnostics, lean startup, minimum value product
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In this thesis, the potential bridging elements that can eventually enable the reduction of the wide gap currently challenging the transition of microfluidic-based in-vitro diagnostic devices (IVDs) from a mostly academic environment toward the successful commercialization of these are highlighted. The principles of lean startup and MVP development were regarded as the optimal framework upon which researchers in the field can rely to achieve the objective aforementioned. Moreover, the adoption of standards to unify the field of microfluidics was also highlighted to be a pivotal aspect to consider, generating uniform practices all across so as to facilitate the development of IVDs and their transition from the lab to the market.


In this thesis, the potential bridging elements that can eventually enable the reduction of the wide gap currently challenging the transition of microfluidic-based in-vitro diagnostic devices (IVDs) from a mostly academic environment toward the successful commercialization of these are highlighted. The principles of lean startup and MVP development were regarded as the optimal framework upon which researchers in the field can rely to achieve the objective aforementioned. Moreover, the adoption of standards to unify the field of microfluidics was also highlighted to be a pivotal aspect to consider, generating uniform practices all across so as to facilitate the development of IVDs and their transition from the lab to the market.

Abstract Acknowledgments Content Chapter 1 Introduction 1.1 Microfluidics: a disruptive technology in biosensing and diagnostics 1.2 The untapped potential of microfluidic-based technologies 1.3 Lean startup model and UI/UX design in the academia-to-commercialization transition 1.4 Materials used in microfluidic-based IVDs fabrication Chapter 2 Microfluidic paper-based analytical devices (µPADs) 2.1 CASE 1: Enhancing the dimensional resolution of µPADs attained by screen-printing fabrication 2.2 CASE 2: Flow control in paper-based microfluidic channels using potassium alum/animal glue coating 2.3 Insights on the feasibility of paper-based microfluidic devices to enable the transition from academia to commercialization Chapter 3 PCB-based approach – Towards total fluidic and biosensing integration of IVDs 3.1 µTAS as the main goal of Lab-on-a-chip- and PCB-based devices 3.2 Ambiguity in the role that PCB-based technology plays in achieving µTAS 3.3 Potential approaches for total integration in PCB-based IVDs Chapter 4 Closing remarks Statement References

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