研究生: |
邱品慈 Pin-Tsu Chiu |
---|---|
論文名稱: |
薄膜型結腸支架與光固化填充材料研究 A Study of Thin Film Type Colonic Stents and UV Curable Filling M aterials |
指導教授: |
張復瑜
Fuh-Yu Chang |
口試委員: |
鄭逸琳
Yih-Lin Cheng 周育任 Yu-Jen Chou 張復瑜 Fuh-Yu Chang |
學位類別: |
碩士 Master |
系所名稱: |
工程學院 - 機械工程系 Department of Mechanical Engineering |
論文出版年: | 2019 |
畢業學年度: | 107 |
語文別: | 中文 |
論文頁數: | 98 |
中文關鍵詞: | 結腸支架 、可降解支架 、光固化聚己内酯 |
外文關鍵詞: | colonic stent, biodegradable stent, UV-curable PCL |
相關次數: | 點閱:190 下載:0 |
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目前在治療結腸腫瘤所造成的阻塞或是防止結腸手術後的吻合口滲漏,常以植入金屬支架作為治療方式。然而,腸道的收縮易造成金屬支架在腸道中滑動位移,且金屬支架不適用於良性腫瘤的治療。因此,薄膜型結腸支架被提出以解決金屬支架的缺點,然此新型支架的開發尚有模具製作及填充材料開發等問題尚待解決。
有鑑於此,本研究結合3D列印技術,以及光固化可降解材料研發,開發薄膜型結腸支架技術。利用降低分子量的方式,合成可光固化、且低熔點之光固化聚己内酯(Polycaprolactone, PCL)填充材料,並利用衍生自3D列印母模的薄膜型模具的良好可撓性,製作出可以符合腸道內彎曲皺褶並避免支架位移的新型腸道支架。
論文實驗結果顯示,透過材料的改質,可以使材料填充溫度降低至30℃,符合人體溫度,以增加充填材料的效率。結合3D列印技術與PCL覆膜技術所製作出的薄膜型支架模具,可以成功填充光固化可降解材料,以完成充填式可降解腸道支架。利用薄膜型支架模具的可撓性,可以使支架完整貼覆於腸道內節與節間隔突起結構,以達成支架位移現象的改善。與市售金屬腸道支架相比,本論文所製作的薄膜型可降解支架,能提供足夠的徑向力,並克服支架位移的瓶頸,對於腸道支架應用具有一定的貢獻。
Currently, in the treatment of colorectal obstruction and the prevention of anastomotic leakage, metal stents are often used as a treatment. However, intestinal peristalsis may cause the migration of metal stents. Therefore, an innovative thin-film type colonic stent is proposed, but the development of this stent is limited by the mold fabrication and physical properties of the filling materials.
To solve these problems, this research aims to improve the thin film type biodegradable colonic stent by applying 3D printing and studying UV curing biodegradable materials. By lowering the molecular weight, a UV-curable and low melting point polycaprolactone (PCL) filling material was made. Due to the good flexibility of the thin-film mold, from the 3D printed master, and the special filling process, the developed thin film type colonic stent was proved to be able to conform the curved folds in the colon and prevent the possible migration.
To confirm whether the method is feasible, the properties of PCL filling material has been analyzed, and the results proved the melting point of the PCL material is under 30C and suitable for performing the filling process in the body temperature. Experiments also proved the developed biodegradable thin film mold, fabricated by 3D printing and dipping process, can be filled with the PCL filling material and cured under UV light successfully to complete the formation of the thin film type colonic stent. The flexibility of the thin-film stent allows it to completely attach to the curving folds inside the colon, which achieves a solution to prevent stent migration. This research designs a new biodegradable stent that provides sufficient radial force, and overcomes the shortage of current biodegradable stents, and provides a possible way to develop biodegradable colonic stents in the future.
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