由於奈米粒子其優異性及可與癌細胞相互作用的性質，在癌症檢測和治療的應用不斷提升。在一些案例中，對於製備含有卓越功能的水溶性奈米粒子仍然存在複雜的方式，以及如何使他們成為一個有功效和有效率的探針於生物應用仍是一個問題。在本研究中，利用相轉移策略，將幾種油溶性奈米粒子包含複合奈米粒子(AgInS2/ZnS)，黄金，四氧化三鐵，及氧化錳鐵，透過溶劑熱合成法製備成水相奈米粒子。該策略的設計藉由一個容易且簡單的相轉換奈米粒子且對原始的奈米粒子性質為最低影響。基本上，有兩種方法透過簡單的相轉移策略可以合成水溶性奈米粒子，其一是利用烷基配位體，此配位體的碳鏈在奈米粒子的表面可以使奈米表面形成親水性。這些碳鏈分子是相當小而可以順利的包覆和防止相轉移的奈米粒子形成聚集。其二，利用蛋白質，即牛血清白蛋白的應用，研究用於同時傳輸不同類型的奈米粒子。這種蛋白可以的透過結合AgInS2/ZnS和MnFe2O4的性質在一起成功形成雙重探測能力（magnetofluorecent奈米簇）。一般情况下，這兩種方法可以產生相當卓越之内穩定的水溶性奈米粒子（針對不同的酸鹼值和鹽濃度）且有顯著無毒性並可以安全地實驗在生物應用。將葉酸和一些抗癌藥物（如cisplatin和 doxorubicin）利用共價鍵或非共價鍵嫁接在奈米粒子上以執行特定癌症的標靶和藥物輸送能力之研究。觀察在光譜分析和核磁共振圖可以顯示這些奈米粒子再嫁接上葉酸或抗癌藥物仍然存在他們的基本性質。幾種體外分析，包括MTT分析法，雷射掃描共軛焦顯微鏡技術，磁共振圖像，穿透式電子顯微鏡 (TEM)和流式細胞術進行了確認設計的奈米粒子作為癌症檢測和治療的效能。

Application of nanoparticles on cancer detection and therapy has been continuously improved due to their fascinating properties when interacted at cancer cells. For several cases, the excellence features offered by nanoparticles remained problems related to complicating way on preparing water-soluble nanoparticles and how make them be an efficient and effective probe for biological application. In the present study, phase transfer strategies were proposed on the several oil-soluble nanoparticles (i.e. AgInS2/ZnS, gold, Fe3O4, and MnFe2O4) that prepared via solvothermal method. The strategies were designed by promoting a facile and simple process within minimize degradation the original properties of transferred nanoparticles. Generally, two approaches would be investigated on providing water-soluble nanoparticles through simple phase transfer strategy; first, utilization of alkyl-capping ligands that will interdigitate with carbon chain on the surface of nanoparticles by performing hydrophilic site as the face. These molecules were quite small, thus can smoothly capsuling and prevent aggregation of transferred nanoparticles. Second, potential application of protein, e.q. bovine serum albumin (BSA), was also investigated for simultaneous transferring and binding different kinds of nanoparticles. BSA can successfully form dual-probing capability (magnetofluorecent nanocluster) by binding AgInS2/ZnS and MnFe2O4 together. In general, the both approaches can fairly generate water-soluble nanoparticles within excellence stability (against varied pH and salt concentration) and non-toxic, thus can be safely implemented on biological application.
For next studies, the as-prepared nanoparticles were directed to performing cancer specific targeting and drug delivery capability. Thus, the folic acid and some cancer drugs (such as cisplatin and doxorubicin) were then conjugated on the nanoparticles using both covalent and non-covalent conjugation. Here, observations with spectra analysis and magnetic resonance could reveal that the nanoparticles still exhibit their basic properties, even after conjugated with proposed agents. Several in vitro analyses, including 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assay, confocal laser microscopy, magnetic resonance images, transmission electron microscopy (TEM), and flow cytometry were carried out to confirming the performance of designed nanoparticles as cancer detection and therapeutic.

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