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研究生: 李宛真
Wan-Chen Lee
論文名稱: 分離血小板採血決策分析
Apheresis Platelet Collecting Decision Analysis
指導教授: 林希偉
Shi-Woei Lin
曹譽鐘
Yu-Chung Tsao
口試委員: 黃麗妃
Li-Fei Huang
學位類別: 碩士
Master
系所名稱: 管理學院 - 工業管理系
Department of Industrial Management
論文出版年: 2016
畢業學年度: 104
語文別: 中文
論文頁數: 70
中文關鍵詞: 分離血小板採血目標時間序列線性規劃季節性自我迴歸移動平均整合模型。
外文關鍵詞: Apheresis platelet, target collection volume, time series, linear Programming, seasonal autoregressive integrated moving averag
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  • 血液的供需管理是當代醫療體系的重要研究議題,由於血液的供給和需求較日常商品不規則且隨機,若存貨管理不當,可能因採血數量與庫存數量不足或過剩而造成極大的社會成本。在血液產品中,血小板(platelet)的保存期僅短短五日,大幅提升管理決策的複雜度,因此如何有效管理血小板之供需,至今仍為學者持續探討的問題。
    本研究期望建構出精準的分離術血小板需求模型以及訂定最佳的採血目標量,提供未來血小板於管理上可行之決策建議。研究中採用時間序列模型之季節性自我迴歸移動平均整合模型(seasonal autoregressive integrated moving average model, SARIMA)進行需求預測,並透過啟發式模型及線性規劃模型分析在不同供應條件下,過期與短缺的變化。分析所得之分離術血小板採血目標,可提高捐血中心在採血及供血管理上的效率,並降低因血液短缺和過期浪費而造成之成本。


    Blood supply and demand management is an important research issue in contemporary health care system. Because the supply and demand of blood are more stochastic and irregular than those of the ordinary commodities and because the blood products are perishable, managing blood supply chain to match supply and demand becomes a challenging task. If the inventory management isn’t appropriate, it would result in the shortage or wastage of blood products and lead to higher social cost. The shelf life of platelets is only five days, which is much shorter compared to other blood products. While solving the platelet collecting and inventory problem is an important decision problem, substantially fewer papers about blood platelets have been published due to the complexity in its nature.
    This research aims to develop a more precise demand model of Apheresis platelet and determine the best target amount of Apheresis platelet collection to provide policy recommendations on the future management of platelets. In the study, seasonal self-regressive moving average integration model (SARIMA) were used to forecast the daily demand of platelets. A heuristic model and a linear programming model were then formulated to solve for the optimal daily target collection volume that minimizes the total social costs. The target collection volume for blood platelet can be easily implemented for the practical situations to enhance the management efficiency of blood collecting and supplying at the blood center, and to decrease the cost of the expired blood wastage and blood shortage.

    第一章、緒論 1 1.1研究背景與動機 1 1.2研究目的與範圍 2 1.3研究流程 2 第二章、文獻回顧 4 2.1台灣捐血現況 4 2.1.1台灣捐血服務發展與內容 4 2.1.2血液製品的供應運作分析 6 2.2血液供應鏈與分離血小板管理 7 2.2.1 預測血液供應與需求 8 2.2.2血液的供需存貨管理 9 2.2.3小結 11 第三章、研究設計與方法 12 3.1研究流程 12 3.2研究問題之建構 14 3.2.1血小板需求現況 14 3.2.2 分離術血小板採集 14 3.2.3 採血流程 15 3.2.4模式變數與參數定義 17 3.2.5 模型架構 18 3.3描述性統計 19 3.4時間序列預測 19 3.4.1 ARIMA 的組合 19 3.4.2 階次選取與參數估計 23 3.4.3模式評估 24 3.5 啟發式模型 26 3.6線性規劃 27 3.6.1 分離術血小板最佳化模型 27 3.7實驗設計 29 第四章、分離術血小板需求預測模型 30 4.1資料收集與特性 30 4.2探索性資料分析 33 4.3建立預測模型 – SARIMA模型 37 4.3.1參數估計與模型檢定 37 4.3.2預測結果 40 4.4建立預測模型 –去季節性模型 41 4.4.1參數估計與模型檢定 41 4.4.2預測結果 43 4.5模型比較 44 第五章、存貨模型建立與決策評估 45 5.1啟發式模型 45 5.1.1 參數及採血目標設定 45 5.1.2分析結果 47 5.2最佳化模型 49 5.2.1採血決策分析 50 5.2.2敏感度分析 51 5.2.3 分離術血小板新鮮度效益之影響 53 5.3模擬真實情境下的供需狀況 55 第六章、結論與建議 58 6.1結論 58 6.2研究限制 59 6.3未來研究建議 60 參考文獻 61

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    網路文獻
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