研究生: |
林珈民 Chia-min Lin |
---|---|
論文名稱: |
表面改質聚甲基丙烯酸甲酯假牙基底材料以增進拉伸強度與抗沾黏效率 Surface modification of acrylic denture material for improvement of tensile strength and antifouling efficiency |
指導教授: |
王孟菊
Meng-jiy Wang |
口試委員: |
劉懷勝
Hwai-shen Liu 廖文堅 Wen-chien Liao 葉昀昇 Yun-shen Yeh |
學位類別: |
碩士 Master |
系所名稱: |
工程學院 - 化學工程系 Department of Chemical Engineering |
論文出版年: | 2011 |
畢業學年度: | 99 |
語文別: | 中文 |
論文頁數: | 70 |
中文關鍵詞: | 表面改質 、電漿處理 、拉伸強度 、抗沾黏 、假牙 |
外文關鍵詞: | surface modification, plasma treatment, adhesion force, antifouling, denture |
相關次數: | 點閱:390 下載:1 |
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假牙材料常見的問題有 (1) 假牙基底材料與軟內襯間黏著力不足,(2) 口腔微生物在假牙材料表面的生長。本研究利用聚甲基丙烯酸甲酯 (polymethyl methacrylate, PMMA)基底的熱固式假牙基底層 (Luctione 199) 以及矽橡膠 (silicone rubber) 基底的熱聚式軟內襯 (Molloplast B) 為實驗材料,並利用射頻電漿系統、多巴胺 (polydopamine) 塗佈和聚乙二醇 (polyethylene glycol, PEG) 改質基材表面,觀察表面性質對於拉伸強度測試以及抗沾黏效率試驗。電漿改質選用氧氣電漿,利用氧氣電漿處理基材表面,可引入含氧官能基,使得材料表面的水濕性提高,水濕性的提高有利於多巴胺塗佈層的吸附量;多巴胺層在本研究所扮演的角色為黏著劑的角色,不論拉伸強度測試與抗沾黏試驗均有存在之必要;抗沾黏高分子選用聚乙二醇,利用聚乙二醇的彈性直鏈重複單體特性,可以將欲貼附於材料表面的生物分子有效的排斥在外,創造出低生物沾黏表面。本研究使用聚乙二醇塗佈於多巴胺改質表面的材料上,可使得改質過後的材料表面與未以多巴胺塗佈的表面比較,抗細胞貼附效率可以提高。
在拉伸強度測試中,探討不同時間氧氣電漿處理假牙基底層表面對於拉伸強度的影響,發現長時間氧氣電漿處理的表面具有較強的拉伸強度,約可上升20.4 %;多巴胺塗佈於氧氣電漿前處理材料表面,可以使得假牙組黏著強度上升約26.5 %;在抗沾黏試驗中,以細胞貼附測試得知,多巴胺吸附的量與表面聚乙二醇有效吸附量有明顯關係,在聚乙二醇吸附於具有多巴胺以及氧氣電漿前處理表面,抗細胞貼附量可達26.3 %。此外,在抗沾黏表面製備部分,本研究也使用戊二醛 (glutaraldehyde )製備交聯聚乙二醇並塗佈於多巴胺及氧氣電漿前處理表面,另外以化學接枝法接枝聚乙二醇於假牙基底層表面,抗沾黏效率分別可以高達47.8 %和60.9 %。
The aims of this study were to improve the adhesion between heat-polymerization denture based material (Luctione 199) and heat-curing soft lining (Molloplast B) and to incorporate anti-fouling properties on the denture based surfaces. The most essential issues for denture materials are the bonding between denture based material and soft lining, and the formation of biofilm from microorganisms in oral. In this study, surface modification methods were used including plasma treatments, polydopamine coating, and polyethylene glycol (PEG) coating. Oxygen was chosen as a plasma gas for introduction of oxygen containing functional groups to increase the surface wettability which facilitated the following adsorption of polydopamine. PEG with elastic repeated unit which repels bimolecular was used as the antifouling polymer. In this study, PEG coating on polydopamine attached surface revealed higher antifouling effects in comparison with the surfaces without the polydopamine coating.
For tensile strength tests, the surfaces treated with oxygen plasma for longer period revealed 20.4 % improvement on the tensile strength. The polydopamine coating further increased the tensile strength 26.5 % in comparing with the pristine sample. The incorporation of PEG showed effects on inhiniting the adhesion of L-929 fibroblasts. Both increase the amount of PEG and the addition of crosslinker assisted the increase of anti-fouling effects up to 47.8 %. Finally, the chemical grafting of PEG on denture based material showed the highest antifouling efficiency with 60.9 %.
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