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研究生： 楊麟翔
Ivan - Yared
論文名稱： 利用氧氣電漿以及聚巴胺塗佈對聚偏二氟乙烯及聚碸進行表面處理
Surface modifications of Polyvinylidene fluoride and Polysulfone by O2 plasma and polydopamine coating
指導教授： 王孟菊
Meng-Jiy Wang
口試委員: 李振綱
Cheng-Kang Lee
劉志成
Jhy-Chern Liu
陳崇賢
Chorng-Shyan Chern
學位類別： 碩士
Master
系所名稱： 工程學院 - 化學工程系
Department of Chemical Engineering
論文出版年： 2010
畢業學年度： 98
語文別： 英文
論文頁數： 126
中文關鍵詞： Surface modification 、polyvinylidene fluoride 、polysulfone 、oxygen plasma 、polydopamine 、cell adhesion 、microfiltration
外文關鍵詞： Surface modification, polyvinylidene fluoride, polysulfone, oxygen plasma, polydopamine, cell adhesion, microfiltration
相關次數： 點閱：318  下載：2 
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    • Oxygen plasma and polydopamine coating were performed on two polymers with excellent mechanical strength and good biocompatibility, polyvinilydene fluoride and polysulfone, to study the effects of surface modifications on the surface physical-chemical properties and on the cell adhesion behaviors.

    O2 plasma altered both PVDF and PSf to more hydrophilic where the WCA reduced more significantly on the O2 plasma treated PSf. By using XPS, the presence of oxygen functionalities on modified surfaces were confirmed and further deconvolution revealed the presence of C-O, C=O, and O-C=O groups. Surface etching occurred on both O2 plasma modified polymers as demonstrated by AFM analysis. On the other hand, the polydopamine coating resulted in similar reduction of WCA and surface composition on both PVDF and PSf which was also confirmed by AFM.

    The biocompatibility was evaluated by directly cultivating L-929 mouse fibroblast cells on pristine and modified PVDF and PSf. For PVDF, the highest cell density, three to four folds than the pristine, was achieved by either O2 plasma modification or polydopamine coating. On the other, for PSf, the polydopamine coating resulted in higher cell density compared with O2 plasma treatment.

    PVDF is widely used for filtration owing to its good mechanical property, thermal stability, and good solvent resistance. The commonly recognized problem of PVDF filtration membrane was the fouling due to the adsorbed protein on the hydrophobic membrane surface which reduced the permeate flux. In this study, the second goal was to reduce protein fouling on Durapore® membrane by surface modification with O2 plasma treatment and polydopamine coating.

    Both O2 plasma modified and polydopamine coated Durapore® membrane showed reduced WCA where O2 plasma treatment resulted in higher surface area due to plasma etching and higher surface electronegativity, the polydoapmine coating reduced membrane surface area and imparted positively-charged functionalities on membrane surface.

    The BSA fouling resistance was created by O2 plasma on Durapore® membrane where the fouling time was delayed by more than 10 min and the flux was higher than the pristine Durapore® membrane. Further reduction of membrane fouling was attained by prolonging plasma treatment time which resulted in more negatively charged surface. On the other hand, the polydopamine coated Durapore® membrane showed rapid flux reduction and no particular anti-fouling property was observed. By performing the dynamic BSA adsorption experiment, it allowed to draw a conclusion that the membrane fouling was strongly affected by the overall resulted properties of surface electrical charge, surface wettability and surface area.

    Oxygen plasma and polydopamine coating were performed on two polymers with excellent mechanical strength and good biocompatibility, polyvinilydene fluoride and polysulfone, to study the effects of surface modifications on the surface physical-chemical properties and on the cell adhesion behaviors.

    O2 plasma altered both PVDF and PSf to more hydrophilic where the WCA reduced more significantly on the O2 plasma treated PSf. By using XPS, the presence of oxygen functionalities on modified surfaces were confirmed and further deconvolution revealed the presence of C-O, C=O, and O-C=O groups. Surface etching occurred on both O2 plasma modified polymers as demonstrated by AFM analysis. On the other hand, the polydopamine coating resulted in similar reduction of WCA and surface composition on both PVDF and PSf which was also confirmed by AFM.

    The biocompatibility was evaluated by directly cultivating L-929 mouse fibroblast cells on pristine and modified PVDF and PSf. For PVDF, the highest cell density, three to four folds than the pristine, was achieved by either O2 plasma modification or polydopamine coating. On the other, for PSf, the polydopamine coating resulted in higher cell density compared with O2 plasma treatment.

    PVDF is widely used for filtration owing to its good mechanical property, thermal stability, and good solvent resistance. The commonly recognized problem of PVDF filtration membrane was the fouling due to the adsorbed protein on the hydrophobic membrane surface which reduced the permeate flux. In this study, the second goal was to reduce protein fouling on Durapore® membrane by surface modification with O2 plasma treatment and polydopamine coating.

    Both O2 plasma modified and polydopamine coated Durapore® membrane showed reduced WCA where O2 plasma treatment resulted in higher surface area due to plasma etching and higher surface electronegativity, the polydoapmine coating reduced membrane surface area and imparted positively-charged functionalities on membrane surface.

    The BSA fouling resistance was created by O2 plasma on Durapore® membrane where the fouling time was delayed by more than 10 min and the flux was higher than the pristine Durapore® membrane. Further reduction of membrane fouling was attained by prolonging plasma treatment time which resulted in more negatively charged surface. On the other hand, the polydopamine coated Durapore® membrane showed rapid flux reduction and no particular anti-fouling property was observed. By performing the dynamic BSA adsorption experiment, it allowed to draw a conclusion that the membrane fouling was strongly affected by the overall resulted properties of surface electrical charge, surface wettability and surface area.

    Abstract i Acknowledgement iii Table of contents iv List of figures ix List of tables xvi Abbreviations xviii Chapter 1. Introduction 1-1 The promotion of biocompatibility on PVDF and PSf 1 1-2 Improvement of filtration performance of PVDF membrane 2 Chapter 2. Literature review 2-1 Polyvinilydene fluoride (PVDF) 5 2-2 Polysulfone (PSf) 6 2-3 Surface modification by oxygen plasma treatment 6 2-4 Surface modification by polydopamine coating 8 2-5 Protein-adsorption-mediated cell adhesion 10 2-5-1 Cell adhesion promotion by O2 plasma treatment 12 2-5-2 Cell adhesion promotion by polydopamine coating 13 2-6 Membrane filtration 14 2-6-1 Microfiltration membrane 14 2-6-2 Crossflow filtration 16 2-7 Membrane fouling by protein 17 2-8 Surface modification to improve membrane performance 18 2-9 Permeate fluxes and hydraulic resistances of microfiltration 19 Chapter 3. Experimental 3-1 Experimental flow chart 29 3-2 Materials 3-2-1 Preparation of polymer thin films 30 3-2-2 Chemicals for preparing polydopamine coating 30 3-2-3 Chemicals for cell culture 30 3-2-4 Chemicals for static protein adsorption 31 3-2-5 Chemicals for cell adhesion studies 31 3-2-6 Chemicals for dynamic protein adsorption 31 3-3 Instruments 32 3-4 Methods 3-4-1 Polymer thin film preparation 33 3-4-2 Surface modification: O2 plasma treatment 33 3-4-3 Surface modification: polydopamine coating 34 3-4-4 Static protein adsorption 34 3-4-5 Cell adhesion 3-4-5-1 Preparation of cell culture medium 35 3-4-5-2 Preparation of solution for LDH (lactate dehydrogenase) analysis 35 3-4-5-3 Cell culture 36 3-4-6 Dynamic protein adsorption 37 3-5 Surface characterization 3-5-1 Water contact angle 38 3-5-2 Attenuated total reflectance (ATR) FT-IR Spectroscopy 38 3-5-3 X-ray photoelectron spectroscopy (XPS) 39 3-5-4 Atomic force microscope (AFM) 39 3-5-5 Scanning electron microscope (SEM) 39 3-5-6 Zeta potential 39 Chapter 4. Results and discussion 4-1 Surface modifications of PVDF by oxygen plasma 4-1-1 Surface wettability of O2 plasma modified PVDF 40 4-1-2 Surface chemical functionality on O2 plasma modified PVDF 41 4-1-3 Surface elemental composition of O2 plasma modified PVDF 43 4-1-4 Surface morphology of O2 plasma modified PVDF 46 4-1-5 Static BSA adsorption on O2 plasma modified PVDF 48 4-1-6 Cell adhesion on O2 plasma modified PVDF 50 4-2 Surface modifications of PSf by oxygen plasma 4-2-1 Surface wettability of O2 plasma modified PSf 53 4-2-2 Surface chemical functionality on O2 plasma modified PSf 54 4-2-3 Surface elemental composition of O2 plasma modified PSf 56 4-2-4 Surface morphology of O2 plasma modified PSf 58 4-2-5 Static BSA adsorption on O2 plasma modified PSf 60 4-2-6 Cell adhesion on O2 plasma modified PSf 62 4-3 Surface modifications of PVDF by polydopamine coating 4-3-1 Surface wettability of polydopamine coated PVDF 64 4-3-2 Surface chemical functionality on polydopamine coated PVDF 65 4-3-3 Surface elemental composition of polydopamine coated PVDF 66 4-3-4 Surface morphology of polydopamine coated PVDF 69 4-3-5 Static BSA adsorption on polydopamine coated PVDF 70 4-3-6 Cell adhesion on polydopamine coated PVDF 71 4-4 Surface modifications of PSf by polydopamine coating 4-4-1 Surface wettability of polydopamine coated PSf 73 4-4-2 Surface chemical functionality on polydopamine coated PSf 74 4-4-3 Surface elemental composition of polydopamine coated PSf 75 4-4-4 Surface morphology of polydopamine coated PSf 77 4-4-5 Static BSA adsorption on polydopamine coated PSf 78 4-4-6 Cell adhesion on polydopamine coated PSf 78 4-5 Dynamic protein adsorption on O2 plasma modified Durapore® membrane 4-5-1 WCA of O2 plasma modified Durapore® membrane 81 4-5-2 Surface morphology of O2 plasma modified Durapore® membrane 82 4-5-3 Zeta potential of O2 plasma modified Durapore® membrane 85 4-5-4 Optimization of MF parameters 4-5-4-1 Effect of TMP and cross flow velocity 86 4-5-4-2 Effect of membrane pretreatment 88 4-5-5 Microfiltration (MF) performance of O2 plasma modified Durapore® membrane 4-5-5-1 Pretreatment by compaction on O2 plasma modified Durapore® membrane 89 4-5-5-2 Pretreatment by ethanol immersion on O2 plasma modified Durapore® membrane 96 4-6 Dynamic protein adsorption on polydopamine coated Durapore® membrane 4-6-1 WCA of O2 polydopamine coated Durapore® membrane 100 4-6-2 Surface morphology of polydopamine coated Durapore® membrane 100 4-6-3 Zeta potential of polydopamine coated Durapore® membrane 103 4-6-4 PEG incorporation onto polydopamine coated substrate 103 4-6-5 Microfiltration (MF) performance of polydopamine coated Durapore® membrane 4-6-5-1 Pretreatment by compaction on polydopamine coated Durapore® membrane 106 4-6-5-2 Pretreatment by ethanol immersion on polydopamine coated Durapore® membrane 110 Chapter 5. Conclusion 115 References 117

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