研究生: |
張慶全 Ching-chuan Chang |
---|---|
論文名稱: |
利用連續式與脈衝式射頻電漿聚合含胺基之高分子薄膜及材料性質分析 Characterization of amine-containing thin films prepared by continuous and pulsed plasma polymerization |
指導教授: |
王孟菊
Meng-Jiy Wang |
口試委員: |
劉懷勝
none 蔡偉博 none 魏大欽 none 李振綱 none |
學位類別: |
碩士 Master |
系所名稱: |
工程學院 - 化學工程系 Department of Chemical Engineering |
論文出版年: | 2008 |
畢業學年度: | 96 |
語文別: | 中文 |
論文頁數: | 130 |
中文關鍵詞: | 連續式電漿 、脈衝式電漿 、能率循環 、電漿聚合 、生物相容性 |
外文關鍵詞: | continuous plasma, pulsed plasma, duty cycle, plasma polymerization, cell biocompatibility |
相關次數: | 點閱:322 下載:1 |
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本論文之研究目的為利用含胺基之單體(丙胺、丙烯胺、丙炔胺),以連續式與脈衝式電漿製備含胺基高分子薄膜。在連續式電漿聚合方面,探討沉積時間、電漿功率對丙胺、丙烯胺、丙炔胺沉積之薄膜性質影響;在脈衝式電漿聚合方面,探討能率循環(duty cycle)對丙胺、丙烯胺、丙炔胺沉積之薄膜性質影響;並就連續式與脈衝式電漿製備之高分子薄膜,探討生物相容性與電漿參數之關係。
由連續式電漿所聚合之高分子薄膜分析結果發現,對飽和以及不飽和之單體,其沉積速率與時間關係為一常數,且正比於電漿功率,在低功率下丙烯胺、丙炔胺具有較高的沉積效能(ng/J),由傅立葉紅外線光譜儀和X射線光電子能譜儀分析結果顯示,丙胺、丙烯胺、丙炔胺薄膜,確實含胺之官能基。同時,利用滴定方法測量胺基數目之結果,發現低電漿功率下具有較高的胺基含量。由脈衝式電漿高聚合之分子薄膜分析結果發現,單體沉積速率與能率循環成正比。經由控制能率循環,由傅立葉紅外線光譜儀和X射線光電子能譜儀分析結果顯示,在低能率循環條件下可獲得富含胺基之丙胺、丙烯胺、丙炔胺薄膜。
對於連續式和脈衝式電漿所製備之含胺基高分子薄膜,利用生物相容性測試結果為:由細胞型態觀察方面,於含胺基之電漿高分子薄膜表面,細胞能夠順利延展並呈現纖維狀形態,推論丙胺、丙烯胺、丙炔胺電漿高分子薄膜都可增進細胞附著、延展以及增生。在細胞活性分析方面,無論是利用連續式或是脈衝式電漿所製備之丙胺、丙烯胺、丙炔胺薄膜,使用纖維母細胞培養之結果,其活性都大於存在於矽基材上之活性。本研究利用連續式與脈衝式電漿,能夠在不同電漿參數下,製備之含胺基之高分子薄膜,並且對於細胞之延展以及活性有提升之作用。
The goal of this research work is to prepare amine-containing polymer thin films by both continuous and pulsed plasma polymerization methods. Three monomers containing various unsaturated structures (propylamine, allylamine, propargylamine) are chosen to provide amine functionalities. The effects of operational parameters such as deposition time, applied power and duty cycle on the physical-chemical properties of polymerized thin films were evaluated by studying their chemical compositions, deposition rates, surface morphology and functionalities.
For both continuous and pulsed plasma polymerizations, the deposition rates were found to be independent of deposition time and proportional to the applied power for three monomers. The surface morphology obtained by AFM showed island structures with nearly constant roughness. This indicates that the surfaces of the thin films prepared by plasma are very uniform. For lower applied power, there exist higher deposition rates for allylamine and propargylamine monomers due to the unsaturated structures. The FTIR and XPS results demonstrated that the amine functional groups have been successfully incorporated onto the thin films for three monomers. The amine derivatization experiments were used to quantify the amine functionalities. The results showed that higher amine concentration can be created at the condition of lower power for both continuous and pulsed plasma polymerization processes. For pulsed plasma polymerization processes, the deposition rate is proportional to the duty cycle.
In order to examine the biocompatibility of amine-containing thin films prepared by plasma polymerizations, the cell behaviors of fibroblasts on these films were monitored. The cell morphology observed by SEM showed that the amine-containing thin films can effectively assist cell spreading. The cell viability was quantified by MTT tests and the results showed that thin films prepared by all these three monomers
can enhance cell viability up to 2.3 folds comparing with the control sample.
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